Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028206557> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2028206557 endingPage "998" @default.
- W2028206557 startingPage "992" @default.
- W2028206557 abstract "Using the MCASE program, a procedure to analyze the diversity of the large amount of available HIV-1 antiviral data was proposed. A subset of 1 819 chemicals was logically selected from the original 14 156 chemicals tested by NCI. This subset of chemicals was shown to contain most of the structural and the functional information of the original database. A full analysis of the 1 819 chemicals by the MCASE program produced a correlation between chemical structures and HIV antiviral activity. In our model, 74 fragments were identified as being responsible for all the chemical's HIV antiviral activity. These fragments may be related to different inhibiting mechanisms, some known and some probably still unknown. The expert system resulting from this analysis can be used to predict the activity of new chemicals and to design new agents that can target multiple enzymes. This was shown to be the case by using the model to predict the activity of 10 diverse chemicals whose activities were not known at the time of model development. Of these, 8 were predicted in agreement with experimental observations. As far as we can tell, this is probably the first project ever to attempt to create a quantitative model of activity for such a massive database of diverse chemicals." @default.
- W2028206557 created "2016-06-24" @default.
- W2028206557 creator A5048507796 @default.
- W2028206557 creator A5070675668 @default.
- W2028206557 date "1999-03-01" @default.
- W2028206557 modified "2023-10-03" @default.
- W2028206557 title "Diversity Analysis of 14 156 Molecules Tested by the National Cancer Institute for Anti-HIV Activity Using the Quantitative Structure−Activity Relational Expert System MCASE" @default.
- W2028206557 cites W1966785965 @default.
- W2028206557 cites W1973288182 @default.
- W2028206557 cites W1976683819 @default.
- W2028206557 cites W1976872345 @default.
- W2028206557 cites W1978168286 @default.
- W2028206557 cites W1994271139 @default.
- W2028206557 cites W1995304507 @default.
- W2028206557 cites W2008764714 @default.
- W2028206557 cites W2028143521 @default.
- W2028206557 cites W2031633486 @default.
- W2028206557 cites W2038577069 @default.
- W2028206557 cites W2049430180 @default.
- W2028206557 cites W2052080593 @default.
- W2028206557 cites W2059863293 @default.
- W2028206557 cites W2060411154 @default.
- W2028206557 cites W2063928997 @default.
- W2028206557 cites W2073761857 @default.
- W2028206557 cites W2086462809 @default.
- W2028206557 cites W2254476898 @default.
- W2028206557 cites W2402784337 @default.
- W2028206557 cites W2950919680 @default.
- W2028206557 cites W2952228498 @default.
- W2028206557 cites W4256221661 @default.
- W2028206557 doi "https://doi.org/10.1021/jm980451i" @default.
- W2028206557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10090782" @default.
- W2028206557 hasPublicationYear "1999" @default.
- W2028206557 type Work @default.
- W2028206557 sameAs 2028206557 @default.
- W2028206557 citedByCount "30" @default.
- W2028206557 countsByYear W20282065572013 @default.
- W2028206557 countsByYear W20282065572022 @default.
- W2028206557 crossrefType "journal-article" @default.
- W2028206557 hasAuthorship W2028206557A5048507796 @default.
- W2028206557 hasAuthorship W2028206557A5070675668 @default.
- W2028206557 hasConcept C144024400 @default.
- W2028206557 hasConcept C159047783 @default.
- W2028206557 hasConcept C185592680 @default.
- W2028206557 hasConcept C19165224 @default.
- W2028206557 hasConcept C193042331 @default.
- W2028206557 hasConcept C202751555 @default.
- W2028206557 hasConcept C21951064 @default.
- W2028206557 hasConcept C2781316041 @default.
- W2028206557 hasConcept C3013748606 @default.
- W2028206557 hasConcept C55493867 @default.
- W2028206557 hasConcept C70721500 @default.
- W2028206557 hasConcept C86803240 @default.
- W2028206557 hasConceptScore W2028206557C144024400 @default.
- W2028206557 hasConceptScore W2028206557C159047783 @default.
- W2028206557 hasConceptScore W2028206557C185592680 @default.
- W2028206557 hasConceptScore W2028206557C19165224 @default.
- W2028206557 hasConceptScore W2028206557C193042331 @default.
- W2028206557 hasConceptScore W2028206557C202751555 @default.
- W2028206557 hasConceptScore W2028206557C21951064 @default.
- W2028206557 hasConceptScore W2028206557C2781316041 @default.
- W2028206557 hasConceptScore W2028206557C3013748606 @default.
- W2028206557 hasConceptScore W2028206557C55493867 @default.
- W2028206557 hasConceptScore W2028206557C70721500 @default.
- W2028206557 hasConceptScore W2028206557C86803240 @default.
- W2028206557 hasIssue "6" @default.
- W2028206557 hasLocation W20282065571 @default.
- W2028206557 hasLocation W20282065572 @default.
- W2028206557 hasOpenAccess W2028206557 @default.
- W2028206557 hasPrimaryLocation W20282065571 @default.
- W2028206557 hasRelatedWork W1814206567 @default.
- W2028206557 hasRelatedWork W2020930729 @default.
- W2028206557 hasRelatedWork W2044634666 @default.
- W2028206557 hasRelatedWork W2056118594 @default.
- W2028206557 hasRelatedWork W2064849054 @default.
- W2028206557 hasRelatedWork W2072777769 @default.
- W2028206557 hasRelatedWork W2330215216 @default.
- W2028206557 hasRelatedWork W2519225373 @default.
- W2028206557 hasRelatedWork W2949431091 @default.
- W2028206557 hasRelatedWork W2987123491 @default.
- W2028206557 hasVolume "42" @default.
- W2028206557 isParatext "false" @default.
- W2028206557 isRetracted "false" @default.
- W2028206557 magId "2028206557" @default.
- W2028206557 workType "article" @default.