Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028213107> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2028213107 endingPage "552" @default.
- W2028213107 startingPage "544" @default.
- W2028213107 abstract "Stroke and stroke-like episodes are frequent complications in mitochondriopathy, particularly in MELAS syndrome (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke like episodes) which is a disorder of the mitochondrial oxidative metabolism in diverse cell types. To clarify a possible pathological aspect of stroke in these patients, we investigated platelet function before and after physical exercise. Ten patients with mitochondriopathy and stroke and ten healthy sex and age matched controls were investigated in an analyst blinded, prospective cross-sectional trial. Exercise decreased intraplatelet adenosine triphosphate (ATP) concentrations by -22% from baseline in patients with mitochondriopathy (p<0.01 between groups) while exercise increased ATP-levels by 28% healthy controls (p=0.01 vs baseline). Thrombin receptor activating peptide (TRAP) stimulated P-selectin expression increased up to 50% (p<0.05) in healthy subjects following exercise compared to 39% (p>0.05) in patients with mitochondriopathy. Exercise trendwise decreased platelet plug formation under shear stress by 24% in patients as measured by the platelet function analyzer PFA-100(R). Tromboelastography showed firm thrombus formation and delayed lysis in patients following exercise. In conclusion, this trial has shown that ATP depletion during and after exercise probably accounts for a defective oxidative metabolism in platelets of patients with mitochondriopathy and stroke. This might induce decreased platelet function in these patients but fails to explain the increased stroke rate. Therefore other mechanisms seem to be etiologically involved in the pathogenesis of stroke in patients with mitochondriopathy." @default.
- W2028213107 created "2016-06-24" @default.
- W2028213107 creator A5000816419 @default.
- W2028213107 creator A5060806470 @default.
- W2028213107 creator A5063002300 @default.
- W2028213107 creator A5068765901 @default.
- W2028213107 creator A5077688632 @default.
- W2028213107 creator A5080941679 @default.
- W2028213107 date "2004-01-01" @default.
- W2028213107 modified "2023-09-25" @default.
- W2028213107 title "Platelet function in mitochondriopathy with stroke and stroke-like episodes" @default.
- W2028213107 doi "https://doi.org/10.1160/th03-03-0156" @default.
- W2028213107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14983231" @default.
- W2028213107 hasPublicationYear "2004" @default.
- W2028213107 type Work @default.
- W2028213107 sameAs 2028213107 @default.
- W2028213107 citedByCount "3" @default.
- W2028213107 countsByYear W20282131072014 @default.
- W2028213107 countsByYear W20282131072019 @default.
- W2028213107 countsByYear W20282131072022 @default.
- W2028213107 crossrefType "journal-article" @default.
- W2028213107 hasAuthorship W2028213107A5000816419 @default.
- W2028213107 hasAuthorship W2028213107A5060806470 @default.
- W2028213107 hasAuthorship W2028213107A5063002300 @default.
- W2028213107 hasAuthorship W2028213107A5068765901 @default.
- W2028213107 hasAuthorship W2028213107A5077688632 @default.
- W2028213107 hasAuthorship W2028213107A5080941679 @default.
- W2028213107 hasConcept C104317684 @default.
- W2028213107 hasConcept C126322002 @default.
- W2028213107 hasConcept C127413603 @default.
- W2028213107 hasConcept C164705383 @default.
- W2028213107 hasConcept C207886595 @default.
- W2028213107 hasConcept C24586158 @default.
- W2028213107 hasConcept C2775833069 @default.
- W2028213107 hasConcept C2776287708 @default.
- W2028213107 hasConcept C2778621155 @default.
- W2028213107 hasConcept C2779564974 @default.
- W2028213107 hasConcept C2780317664 @default.
- W2028213107 hasConcept C2780645631 @default.
- W2028213107 hasConcept C55493867 @default.
- W2028213107 hasConcept C71924100 @default.
- W2028213107 hasConcept C78519656 @default.
- W2028213107 hasConcept C86803240 @default.
- W2028213107 hasConcept C89560881 @default.
- W2028213107 hasConceptScore W2028213107C104317684 @default.
- W2028213107 hasConceptScore W2028213107C126322002 @default.
- W2028213107 hasConceptScore W2028213107C127413603 @default.
- W2028213107 hasConceptScore W2028213107C164705383 @default.
- W2028213107 hasConceptScore W2028213107C207886595 @default.
- W2028213107 hasConceptScore W2028213107C24586158 @default.
- W2028213107 hasConceptScore W2028213107C2775833069 @default.
- W2028213107 hasConceptScore W2028213107C2776287708 @default.
- W2028213107 hasConceptScore W2028213107C2778621155 @default.
- W2028213107 hasConceptScore W2028213107C2779564974 @default.
- W2028213107 hasConceptScore W2028213107C2780317664 @default.
- W2028213107 hasConceptScore W2028213107C2780645631 @default.
- W2028213107 hasConceptScore W2028213107C55493867 @default.
- W2028213107 hasConceptScore W2028213107C71924100 @default.
- W2028213107 hasConceptScore W2028213107C78519656 @default.
- W2028213107 hasConceptScore W2028213107C86803240 @default.
- W2028213107 hasConceptScore W2028213107C89560881 @default.
- W2028213107 hasIssue "03" @default.
- W2028213107 hasLocation W20282131071 @default.
- W2028213107 hasLocation W20282131072 @default.
- W2028213107 hasOpenAccess W2028213107 @default.
- W2028213107 hasPrimaryLocation W20282131071 @default.
- W2028213107 hasRelatedWork W2012135961 @default.
- W2028213107 hasRelatedWork W2013077475 @default.
- W2028213107 hasRelatedWork W2066245922 @default.
- W2028213107 hasRelatedWork W2412853806 @default.
- W2028213107 hasRelatedWork W2566617483 @default.
- W2028213107 hasRelatedWork W2587655298 @default.
- W2028213107 hasRelatedWork W2887157211 @default.
- W2028213107 hasRelatedWork W2963292281 @default.
- W2028213107 hasRelatedWork W2970152981 @default.
- W2028213107 hasRelatedWork W2990101271 @default.
- W2028213107 hasVolume "91" @default.
- W2028213107 isParatext "false" @default.
- W2028213107 isRetracted "false" @default.
- W2028213107 magId "2028213107" @default.
- W2028213107 workType "article" @default.