Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028220971> ?p ?o ?g. }
- W2028220971 endingPage "472" @default.
- W2028220971 startingPage "451" @default.
- W2028220971 abstract "In the last decades, the active research in the field of tumor angiogenesis led to the development of a class of agents providing an effective inhibition of neovessels formation through the blockade of VEGF-related pathways. More recently, the identification of several non-VEGF factors such as PDGF, FGF, HGF, angiopoietins, ALK1/endoglin, endothelis and ephrins involved in tumor angiogenesis have emphasized the need to develop agents targeting multiple pro-angiogenic pathways.This review aimed at summarizing the role of non-VEGF molecular pathways in targeting tumor angiogenesis. Preclinical and clinical data for investigational agents against non-VEGF targets have been reviewed emphasizing the role of combined inhibition strategies.Besides the successful development of drugs providing a specific VEGF blockade, novel agents targeting alternative angiogenesis-related pathways are being tested. Although it seems that the potential clinical usefulness of these novel compounds have been not yet fully investigated, sunitinib, sorafenib, pazopanib and other multikinase inhibitors have certainly displayed encouraging results. A more in-depth clarification of anti-angiogenic agents is still needed, in order to design the best clinical setting and schedule for target-based agents and possibly anticipate potential tools to overcome the emerging issue of anti-angiogenic drug resistance." @default.
- W2028220971 created "2016-06-24" @default.
- W2028220971 creator A5020790343 @default.
- W2028220971 creator A5029193050 @default.
- W2028220971 creator A5030229940 @default.
- W2028220971 date "2012-02-20" @default.
- W2028220971 modified "2023-10-01" @default.
- W2028220971 title "Novel targets for VEGF-independent anti-angiogenic drugs" @default.
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