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- W2028226502 abstract "ISOMURA, K., NIKAIDO, O., HORIKAWA, iIM., AND SUGAHARA, T. Repair of DNA Damage in Ultraviolet-Sensitive Cells Isolated from HeLa S3 Cells. Radiat. Res. 53, 143-152 (1973). Two ultraviolet-sensitive cell lines, designated S-1M and S-2M, were isolated from the original HeLa 83 cells by the N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-ultraviolet light (UV) and 5-bromodeoxyuridine (BUdR)-visible light method. The Do values were 87, 68, and 45 ergs/mm2, and the extrapolation numbers (n) were 1.4, 1.0, and 1.0 for HeLa 83, S-1M, and S-2M cells, respectively. The average initial excision rate of UV-induced thymine dimers in the UV-sensitive cells is approximately one fifth that in HeLa S3 cells. The UV-sensitive cells may appear in the original HeLa S3 population due to the mutagenic action of MNNG. S-2M cells are more sensitive to the carcinogen 4-nitroquinoline 1-oxide (4-NQO) than HeLa S3 cells. However, there are no significant differences in sensitivity to x-irradiation among the three cell lines. The findings indicate that the 4-NQO-induced DNA damage and its repair are similar to that found after UV-irradiation, but different from that found after x-irradiation." @default.
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- W2028226502 date "1973-01-01" @default.
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- W2028226502 title "Repair of DNA Damage in Ultraviolet-Sensitive Cells Isolated from HeLa S3 Cells" @default.
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- W2028226502 doi "https://doi.org/10.2307/3573455" @default.
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