FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028227989> ?p ?o ?g. }

• W2028227989 endingPage "2599" @default.
• W2028227989 startingPage "2595" @default.
• W2028227989 abstract "The molecular and cellular events mediating complex behaviors in animals are largely unknown. Elucidating the circuits underlying behaviors in simple model systems may shed light on how these circuits function. In drosophila, courtship behavior provides a tractable model for studying the underlying basis of innate behavior. The male-specific pheromone 11- cis- vaccenyl acetate (cVA) modulates courtship behavior and is detected by T1 neurons, located on the antenna of male and female flies. The T1 neurons express the odorant receptor Or67d and are exquisitely tuned to cVA pheromone. However, cVA-induced changes in mating behavior have also been reported upon manipulation of olfactory neurons expressing odorant receptor Or65a. These findings raise the issue of whether multiple olfactory-driven circuits underlie cVA-induced behavioral responses and what role these circuits play in behavior. Here, we engineered flies in which the Or67d circuit is specifically activated in the absence of cVA to determine the role of this circuit in behavior. We created transgenic flies that express a dominant-active, pheromone-independent variant of the extracellular pheromone receptor, LUSH. We found that, similar to the behaviors elicited by cVA, engineered male flies have dramatically reduced courtship, whereas engineered females showed enhanced courtship. cVA exposure did not enhance the dominant LUSH-triggered effects on behavior in the engineered flies. Finally, we show the effects of both cVA and dominant LUSH on courtship are reversed by genetically removing Or67d. These findings demonstrate that the T1/Or67d circuit is necessary and sufficient to mediate sexually dimorphic courtship behaviors." @default.
• W2028227989 created "2016-06-24" @default.
• W2028227989 creator A5004761719 @default.
• W2028227989 creator A5038792851 @default.
• W2028227989 date "2010-02-17" @default.
• W2028227989 modified "2023-10-14" @default.
• W2028227989 title "Activation of the T1 Neuronal Circuit is Necessary and Sufficient to Induce Sexually Dimorphic Mating Behavior in<i>Drosophila melanogaster</i>" @default.
• W2028227989 cites W1600642016 @default.
• W2028227989 cites W1965123365 @default.
• W2028227989 cites W1971079677 @default.
• W2028227989 cites W1980403687 @default.
• W2028227989 cites W1988459789 @default.
• W2028227989 cites W2002141216 @default.
• W2028227989 cites W2004788565 @default.
• W2028227989 cites W2017112196 @default.
• W2028227989 cites W2021892293 @default.
• W2028227989 cites W2039568017 @default.
• W2028227989 cites W2044679952 @default.
• W2028227989 cites W2049174326 @default.
• W2028227989 cites W2054478667 @default.
• W2028227989 cites W2091501985 @default.
• W2028227989 cites W2093232181 @default.
• W2028227989 cites W2100539697 @default.
• W2028227989 cites W2102465785 @default.
• W2028227989 cites W2115354701 @default.
• W2028227989 cites W2117983072 @default.
• W2028227989 cites W2141891129 @default.
• W2028227989 cites W2157159187 @default.
• W2028227989 cites W2168442632 @default.
• W2028227989 doi "https://doi.org/10.1523/jneurosci.4819-09.2010" @default.
• W2028227989 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3426441" @default.
• W2028227989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20164344" @default.
• W2028227989 hasPublicationYear "2010" @default.
• W2028227989 type Work @default.
• W2028227989 sameAs 2028227989 @default.
• W2028227989 citedByCount "42" @default.
• W2028227989 countsByYear W20282279892012 @default.
• W2028227989 countsByYear W20282279892013 @default.
• W2028227989 countsByYear W20282279892014 @default.
• W2028227989 countsByYear W20282279892015 @default.
• W2028227989 countsByYear W20282279892016 @default.
• W2028227989 countsByYear W20282279892017 @default.
• W2028227989 countsByYear W20282279892018 @default.
• W2028227989 countsByYear W20282279892019 @default.
• W2028227989 countsByYear W20282279892020 @default.
• W2028227989 countsByYear W20282279892022 @default.
• W2028227989 countsByYear W20282279892023 @default.
• W2028227989 crossrefType "journal-article" @default.
• W2028227989 hasAuthorship W2028227989A5004761719 @default.
• W2028227989 hasAuthorship W2028227989A5038792851 @default.
• W2028227989 hasBestOaLocation W20282279891 @default.
• W2028227989 hasConcept C104317684 @default.
• W2028227989 hasConcept C118403218 @default.
• W2028227989 hasConcept C130039590 @default.
• W2028227989 hasConcept C163214680 @default.
• W2028227989 hasConcept C169760540 @default.
• W2028227989 hasConcept C2776041557 @default.
• W2028227989 hasConcept C2776453541 @default.
• W2028227989 hasConcept C2777328355 @default.
• W2028227989 hasConcept C2779980732 @default.
• W2028227989 hasConcept C2780050217 @default.
• W2028227989 hasConcept C2780104201 @default.
• W2028227989 hasConcept C514575182 @default.
• W2028227989 hasConcept C54355233 @default.
• W2028227989 hasConcept C64778439 @default.
• W2028227989 hasConcept C74254510 @default.
• W2028227989 hasConcept C86803240 @default.
• W2028227989 hasConcept C90856448 @default.
• W2028227989 hasConcept C95444343 @default.
• W2028227989 hasConceptScore W2028227989C104317684 @default.
• W2028227989 hasConceptScore W2028227989C118403218 @default.
• W2028227989 hasConceptScore W2028227989C130039590 @default.
• W2028227989 hasConceptScore W2028227989C163214680 @default.
• W2028227989 hasConceptScore W2028227989C169760540 @default.
• W2028227989 hasConceptScore W2028227989C2776041557 @default.
• W2028227989 hasConceptScore W2028227989C2776453541 @default.
• W2028227989 hasConceptScore W2028227989C2777328355 @default.
• W2028227989 hasConceptScore W2028227989C2779980732 @default.
• W2028227989 hasConceptScore W2028227989C2780050217 @default.
• W2028227989 hasConceptScore W2028227989C2780104201 @default.
• W2028227989 hasConceptScore W2028227989C514575182 @default.
• W2028227989 hasConceptScore W2028227989C54355233 @default.
• W2028227989 hasConceptScore W2028227989C64778439 @default.
• W2028227989 hasConceptScore W2028227989C74254510 @default.
• W2028227989 hasConceptScore W2028227989C86803240 @default.
• W2028227989 hasConceptScore W2028227989C90856448 @default.
• W2028227989 hasConceptScore W2028227989C95444343 @default.
• W2028227989 hasIssue "7" @default.
• W2028227989 hasLocation W20282279891 @default.
• W2028227989 hasLocation W20282279892 @default.
• W2028227989 hasLocation W20282279893 @default.
• W2028227989 hasLocation W20282279894 @default.
• W2028227989 hasOpenAccess W2028227989 @default.
• W2028227989 hasPrimaryLocation W20282279891 @default.
• W2028227989 hasRelatedWork W1679607429 @default.
• W2028227989 hasRelatedWork W1971079677 @default.
• W2028227989 hasRelatedWork W2028227989 @default.
• W2028227989 hasRelatedWork W2051247057 @default.

• next