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- W2028231103 abstract "A 25-year-old African American woman presented with a chief complaint of generalized pain. She carried a diagnosis of sickle cell anemia and history of repeated hospitalizations for generalized pain treated with narcotic analgesics. Her hematological parameters revealed hemoglobin 7.2 g/dL with hematocrit 24%, mean corpuscular volume 56 fl, mean corpuscular hemoglobin 16.7 pg, mean corpuscular hemoglobin concentration 29.9%, red blood cell distribution width 20.6%, and absolute reticulocyte count 0.067 M/μL. The initial red cell morphology was read by the laboratory as containing sickled cells (Figure 1). She was iron deficient (ferritin of 6 μg/L with iron 14 μg/dL, % iron saturation of 4, and iron-binding capacity 374 μg/dL). Interestingly, a urinalysis was also obtained, which demonstrated a specific gravity of 1.020. Because of this evidence of preserved concentrating ability, we performed a hemoglobin electrophoresis, looking for less severe disease variants (eg, sickle-C disease). Surprisingly, we found her electrophoresis to be normal (repeated and confirmed). Formal pathological review of peripheral blood smear revealed that the abnormal erythrocytes were elliptocytes. These elliptocytes were due to either her severe iron deficiency or other disorders enumerated below. Interestingly, when the patient was informed that she did not have sickle cell anemia, she expressed no surprise and immediately asked to be discharged from the hospital. Unfortunately, the patient has not returned for any follow-up appointments." @default.
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- W2028231103 date "2009-10-01" @default.
- W2028231103 modified "2023-09-26" @default.
- W2028231103 title "“Pseudo-Sickle” Cell Anemia" @default.
- W2028231103 doi "https://doi.org/10.1097/maj.0b013e31819f1ec1" @default.
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