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• W2028232000 abstract "In this study we investigated which type of T cells: high T-cell receptor (TCRhigh, cells of thymic origin) or intermediate TCR (TCRint, cells of extrathymic origin), expanded in the liver and other organs, resulting in the induction of graft-versus-host disease (GVHD) with minor lymphocyte stimulating (M1s) disparity. When 6.5 Gy-irradiated BALB/c (H-2d M1s-1b2a) mice were injected with interleukin-2 receptor β-chain− (IL-2Rβ−) CD3high cells purified from the spleen of B10.D2 (H-2d M1s-1b2b) mice, IL-2Rβ+CD3high cells expanded in the liver and other organs of recipient mice. The majority of these cells were found to be IL-2Rα−Mel-14−CD4+Vβ3+ in GVHD mice. The CDR3 region in their TCR-αβ (i.e. N–Dβ–N) was polyclonal, although there were skewed usages of Vβ3 and Jβ2.4. The majority of cells were confirmed to be of donor origin by the individual discrimination method, namely, they originated from isolated IL-2Rβ−CD3high cells. Interestingly, these T cells lacked cytotoxicity against both a natural killer (NK)-sensitive target and thymocytes with M1s disparity and nondisparity. Another important finding was that activated granulocytes expanded at generalized sites in GVHD mice. The present results raise the possibility that M1s disparity is mainly recognized by TCRhigh cells with unique properties but that direct effector cells that induce GVHD might not be such T cells but rather accompanied granulocytes." @default.
• W2028232000 created "2016-06-24" @default.
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• W2028232000 date "1999-03-01" @default.
• W2028232000 modified "2023-09-26" @default.
• W2028232000 title "Mechanisms Involved in Graft-Versus-Host Disease Induced by the Disparity of Minor Histocompatibility M1s Antigens" @default.
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• W2028232000 doi "https://doi.org/10.1046/j.1365-3083.1999.00497.x" @default.
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