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• W2028236452 abstract "Ca(2+) influx through NMDA receptors (NMDA-Rs) triggers synaptic plasticity, gene transcription, and cytotoxicity, but little is known about the regulation of NMDA-Rs themselves. We used two-photon glutamate uncaging to activate NMDA-Rs on individual dendritic spines in rat CA1 neurons while we measured NMDA-R currents at the soma and [Ca(2+)] changes in spines. Low-frequency uncaging trains induced Ca(2+)-dependent long-term depression of NMDA-R-mediated synaptic currents. Additionally, uncaging trains caused a reduction in the Ca(2+) accumulation per unit of NMDA-R current in spines due to a reduction in the fraction of the NMDA-R current carried by Ca(2+). Induction of depression of NMDA-R-mediated Ca(2+) influx required activation of NR2B-containing receptors. Receptors in single spines depressed rapidly in an all-or-none manner. These adaptive changes in NMDA-R function likely play a critical role in metaplasticity and in stabilizing activity levels in neuronal networks with Hebbian synapses." @default.
• W2028236452 created "2016-06-24" @default.
• W2028236452 creator A5033753331 @default.
• W2028236452 creator A5088944052 @default.
• W2028236452 date "2007-01-01" @default.
• W2028236452 modified "2023-09-30" @default.
• W2028236452 title "Activity-Dependent Plasticity of the NMDA-Receptor Fractional Ca2+ Current" @default.
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• W2028236452 doi "https://doi.org/10.1016/j.neuron.2006.11.016" @default.
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