Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028236469> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2028236469 endingPage "597" @default.
- W2028236469 startingPage "590" @default.
- W2028236469 abstract "<h3>Objective:</h3> To assess pregabalin monotherapy for partial-onset seizures using a historical-controlled conversion-to-monotherapy design. <h3>Methods:</h3> Adults with inadequately controlled partial-onset seizures while receiving 1 or 2 antiepileptic drugs during an 8-week prospective baseline were randomized to double-blind monotherapy with pregabalin 600 or 150 mg/d (4:1) for 20 weeks (8-week conversion and 12-week monotherapy period). The primary endpoint was the seizure-related exit rate for pregabalin 600 mg/d, based on discontinuations due to predefined criteria. Efficacy was declared if the upper limit of the 95% confidence interval for the exit rate was below a historical-control threshold of 74%, with stepwise evaluation using a threshold of 68%. <h3>Results:</h3> The trial was stopped early for positive efficacy after an interim analysis in 125 patients. The full study population included 161 patients, with 148 evaluable for efficacy. The mean time since epilepsy diagnosis was 14 years. Overall, 54.3% (600 mg/d) and 46.9% (150 mg/d) of patients completed 20 weeks of double-blind treatment. Seizure-related exit rate in the 600 mg/d group (27.5%; 95% confidence interval, 17.8%–37.2%) was significantly below the 74% and 68% thresholds (<i>p</i> < 0.001 for both). Eight patients on 600 mg/d and 2 on 150 mg/d were seizure-free throughout pregabalin monotherapy. Pregabalin9s overall safety profile was consistent with prior trials. <h3>Conclusions:</h3> Pregabalin monotherapy was safe and efficacious for patients with inadequately controlled partial-onset seizures. <h3>Classification of evidence:</h3> This study provides Class III evidence that patients with inadequately controlled partial-onset seizures switched to pregabalin monotherapy have fewer seizure-related exit events compared with historical controls switched to pseudo-placebo monotherapy." @default.
- W2028236469 created "2016-06-24" @default.
- W2028236469 creator A5000088747 @default.
- W2028236469 creator A5007443039 @default.
- W2028236469 creator A5033312294 @default.
- W2028236469 creator A5040362413 @default.
- W2028236469 creator A5045036945 @default.
- W2028236469 creator A5049222594 @default.
- W2028236469 creator A5067443324 @default.
- W2028236469 date "2014-01-10" @default.
- W2028236469 modified "2023-10-18" @default.
- W2028236469 title "Pregabalin monotherapy in patients with partial-onset seizures: A historical-controlled trial" @default.
- W2028236469 cites W1756081881 @default.
- W2028236469 cites W1998083304 @default.
- W2028236469 cites W2016447647 @default.
- W2028236469 cites W2045880997 @default.
- W2028236469 cites W2059212626 @default.
- W2028236469 cites W2075042249 @default.
- W2028236469 cites W2078797427 @default.
- W2028236469 cites W2090188920 @default.
- W2028236469 cites W2116043268 @default.
- W2028236469 doi "https://doi.org/10.1212/wnl.0000000000000119" @default.
- W2028236469 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3963419" @default.
- W2028236469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24415567" @default.
- W2028236469 hasPublicationYear "2014" @default.
- W2028236469 type Work @default.
- W2028236469 sameAs 2028236469 @default.
- W2028236469 citedByCount "25" @default.
- W2028236469 countsByYear W20282364692014 @default.
- W2028236469 countsByYear W20282364692015 @default.
- W2028236469 countsByYear W20282364692016 @default.
- W2028236469 countsByYear W20282364692017 @default.
- W2028236469 countsByYear W20282364692018 @default.
- W2028236469 countsByYear W20282364692019 @default.
- W2028236469 countsByYear W20282364692021 @default.
- W2028236469 countsByYear W20282364692022 @default.
- W2028236469 crossrefType "journal-article" @default.
- W2028236469 hasAuthorship W2028236469A5000088747 @default.
- W2028236469 hasAuthorship W2028236469A5007443039 @default.
- W2028236469 hasAuthorship W2028236469A5033312294 @default.
- W2028236469 hasAuthorship W2028236469A5040362413 @default.
- W2028236469 hasAuthorship W2028236469A5045036945 @default.
- W2028236469 hasAuthorship W2028236469A5049222594 @default.
- W2028236469 hasAuthorship W2028236469A5067443324 @default.
- W2028236469 hasBestOaLocation W20282364692 @default.
- W2028236469 hasConcept C118552586 @default.
- W2028236469 hasConcept C126322002 @default.
- W2028236469 hasConcept C168563851 @default.
- W2028236469 hasConcept C203092338 @default.
- W2028236469 hasConcept C2776468701 @default.
- W2028236469 hasConcept C2778186239 @default.
- W2028236469 hasConcept C2908647359 @default.
- W2028236469 hasConcept C42219234 @default.
- W2028236469 hasConcept C44249647 @default.
- W2028236469 hasConcept C61943457 @default.
- W2028236469 hasConcept C71924100 @default.
- W2028236469 hasConcept C99454951 @default.
- W2028236469 hasConceptScore W2028236469C118552586 @default.
- W2028236469 hasConceptScore W2028236469C126322002 @default.
- W2028236469 hasConceptScore W2028236469C168563851 @default.
- W2028236469 hasConceptScore W2028236469C203092338 @default.
- W2028236469 hasConceptScore W2028236469C2776468701 @default.
- W2028236469 hasConceptScore W2028236469C2778186239 @default.
- W2028236469 hasConceptScore W2028236469C2908647359 @default.
- W2028236469 hasConceptScore W2028236469C42219234 @default.
- W2028236469 hasConceptScore W2028236469C44249647 @default.
- W2028236469 hasConceptScore W2028236469C61943457 @default.
- W2028236469 hasConceptScore W2028236469C71924100 @default.
- W2028236469 hasConceptScore W2028236469C99454951 @default.
- W2028236469 hasIssue "7" @default.
- W2028236469 hasLocation W20282364691 @default.
- W2028236469 hasLocation W20282364692 @default.
- W2028236469 hasLocation W20282364693 @default.
- W2028236469 hasLocation W20282364694 @default.
- W2028236469 hasOpenAccess W2028236469 @default.
- W2028236469 hasPrimaryLocation W20282364691 @default.
- W2028236469 hasRelatedWork W1977125423 @default.
- W2028236469 hasRelatedWork W2022417792 @default.
- W2028236469 hasRelatedWork W2114983792 @default.
- W2028236469 hasRelatedWork W2244282381 @default.
- W2028236469 hasRelatedWork W2319724413 @default.
- W2028236469 hasRelatedWork W2950976910 @default.
- W2028236469 hasRelatedWork W2956014051 @default.
- W2028236469 hasRelatedWork W3082225243 @default.
- W2028236469 hasRelatedWork W4235710562 @default.
- W2028236469 hasRelatedWork W3037250214 @default.
- W2028236469 hasVolume "82" @default.
- W2028236469 isParatext "false" @default.
- W2028236469 isRetracted "false" @default.
- W2028236469 magId "2028236469" @default.
- W2028236469 workType "article" @default.