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- W2028236484 abstract "The effects of X-irradiation of the eye on ocular parameters known to be altered during the inflammatory process were studied on albino and pigmented rabbits, guinea pigs, owl monkeys, cats, ducks and pigeons. Within 1·5–3·0 hr after exposure to 10 Gy (1000 rads), all irradiated eyes of either albino or pigmented rabbits showed a significant increase in intraocular pressure, iridial hyperemia, and development of flare and presence of cells in the anterior chamber. Four hours after exposure, the concentration of soluble proteins in the aqueous humor was increased, while that of ascorbic acid was decreased. In contrast, eyes of owl monkeys, cats, guinea pigs, ducks and pigeons, exposed to the same or, in some cases, up to eight times higher doses of X-rays, showed no hypertension or development of other parameters of intraocular inflammation. These and previous findings suggest that rabbits, or possibly Lagomorphs in general, are unique among vertebrates in their sensitivity to the early intraocular inflammatory effects of X-rays. In addition, these results seriously question the use of this species as the primary, and frequently sole model for the study of ocular inflammation, its mediation and therapeutics." @default.
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- W2028236484 title "The unique sensitivity of the rabbit eye to X-ray-induced ocular inflammation" @default.
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- W2028236484 doi "https://doi.org/10.1016/s0014-4835(81)80092-9" @default.
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