FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028238051> ?p ?o ?g. }

• W2028238051 endingPage "1420" @default.
• W2028238051 startingPage "1420" @default.
• W2028238051 abstract "<h3>Importance</h3> The need to respond quickly to potential influenza pandemics is important. Immunologic priming (initial presentation of an antigen to allow antibody responses on revaccination) with vaccine directed toward an older avian influenza H5 strain might lead to secondary antibody responses to a single dose of more current H5 avian influenza vaccine. <h3>Objectives</h3> To assess priming with the older avian influenza A/Vietnam/1203/2004(H5N1) (Vietnam) vaccine and to conduct dose-response studies with vaccine directed against the more contemporary H5N1 avian influenza virus, influenza A/Anhui/01/2005 (Anhui). <h3>Design, Setting, and Participants</h3> Multicenter US randomized clinical trial beginning in June 2010 with follow-up continuing through October 2011 enrolling 72 healthy adults who were vaccinated 19 to 25 months previously with the Vietnam vaccine and 565 vaccine-naive adults. <h3>Interventions</h3> Participants who were previously vaccinated with 90 µg of unadjuvanted Vietnam vaccine were randomly assigned to receive 3.75 µg of avian influenza Anhui vaccine with or without MF59 adjuvant, stratified by 1 vs 2 previous doses (1 dose: n = 18 with MF59 and n = 17 without; 2 doses: n = 19 with MF59 and n = 18 without). Vaccine-naive individuals were randomly assigned to receive Ahnui vaccine with or without MF59 adjuvant in 1 of 5 doses (3.75 µg [n = 55 with MF59 and n = 59 without], 7.5 µg [n = 51 with MF59 and n = 57 without], 15 µg [n = 48 with MF59 and n = 44 without], 45 µg [n = 47 with MF59 and n = 47 without], or 90 µg [n = 57 without adjuvant]) or placebo (n = 100) given at days 0 and 28. <h3>Main Outcomes and Measures</h3> The primary immunogenicity outcome was hemagglutination inhibition assay (HAI) titer against each vaccine antigen 1 month (day 28) and 6 months (day 180) after last vaccination. The primary safety outcomes were local and systemic adverse events on days 0 to 7 after each vaccination and serious adverse events. <h3>Results</h3> Previously vaccinated participants manifested secondary antibody responses after receipt of low-dose Anhui vaccine (“boosting”); by day 28, 21% to 50% developed HAI responses of 1:40 or greater. Use of adjuvant was not associated with increased HAI responses. Among vaccine-naive participants (n = 565), the optimum dose was 7.5 µg of antigen with adjuvant (geometric mean titer [GMT], 63.3; 95% CI, 43.0-93.1). The greatest response to unadjuvanted antigen was seen at the highest dose, 90 µg (GMT, 28.5; 95% CI, 19.7-41.2). Local or systemic reactions occurred, respectively, in 40 (78%) and 25 (49%) of 51 participants who received 7.5 µg plus adjuvant vs 50 (88%) and 29 (51%) of 57 who received 90 µg of unadjuvanted vaccine. In general, antibodies were short-lived, and by day 180, HAI titers had decreased to less than 1:20 in all treatment groups. <h3>Conclusions and Relevance</h3> Previous receipt of a single dose of influenza A(H5N1) Vietnam vaccine was associated with sufficient immunologic priming to facilitate antibody response to a different H5N1 antigen using low-dose Anhui (booster) vaccine. In participants who had not previously received H5 vaccine, low-dose Anhui vaccine plus adjuvant was more immunogenic compared with higher doses of unadjuvanted vaccine. <h3>Trial Registration</h3> clinicaltrials.gov Identifier:NCT00680069" @default.
• W2028238051 created "2016-06-24" @default.
• W2028238051 creator A5005432740 @default.
• W2028238051 creator A5005747264 @default.
• W2028238051 creator A5007833163 @default.
• W2028238051 creator A5012154124 @default.
• W2028238051 creator A5014624716 @default.
• W2028238051 creator A5016037005 @default.
• W2028238051 creator A5020891630 @default.
• W2028238051 creator A5022441333 @default.
• W2028238051 creator A5022867637 @default.
• W2028238051 creator A5036112915 @default.
• W2028238051 creator A5041183761 @default.
• W2028238051 creator A5045519730 @default.
• W2028238051 creator A5048682080 @default.
• W2028238051 creator A5054605942 @default.
• W2028238051 creator A5064116200 @default.
• W2028238051 creator A5067425596 @default.
• W2028238051 creator A5069302574 @default.
• W2028238051 creator A5075227924 @default.
• W2028238051 creator A5078714130 @default.
• W2028238051 date "2014-10-08" @default.
• W2028238051 modified "2023-10-14" @default.
• W2028238051 title "Immunogenicity of Avian Influenza A/Anhui/01/2005(H5N1) Vaccine With MF59 Adjuvant" @default.
• W2028238051 cites W2013230062 @default.
• W2028238051 cites W2025333144 @default.
• W2028238051 cites W2036596307 @default.
• W2028238051 cites W2079080326 @default.
• W2028238051 cites W2101877224 @default.
• W2028238051 cites W2118362676 @default.
• W2028238051 cites W2130490068 @default.
• W2028238051 cites W2131170401 @default.
• W2028238051 cites W2147450840 @default.
• W2028238051 cites W2155467153 @default.
• W2028238051 cites W2162384187 @default.
• W2028238051 cites W2170877664 @default.
• W2028238051 cites W2253260847 @default.
• W2028238051 doi "https://doi.org/10.1001/jama.2014.12609" @default.
• W2028238051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25291578" @default.
• W2028238051 hasPublicationYear "2014" @default.
• W2028238051 type Work @default.
• W2028238051 sameAs 2028238051 @default.
• W2028238051 citedByCount "45" @default.
• W2028238051 countsByYear W20282380512014 @default.
• W2028238051 countsByYear W20282380512015 @default.
• W2028238051 countsByYear W20282380512016 @default.
• W2028238051 countsByYear W20282380512017 @default.
• W2028238051 countsByYear W20282380512018 @default.
• W2028238051 countsByYear W20282380512019 @default.
• W2028238051 countsByYear W20282380512020 @default.
• W2028238051 countsByYear W20282380512021 @default.
• W2028238051 countsByYear W20282380512022 @default.
• W2028238051 countsByYear W20282380512023 @default.
• W2028238051 crossrefType "journal-article" @default.
• W2028238051 hasAuthorship W2028238051A5005432740 @default.
• W2028238051 hasAuthorship W2028238051A5005747264 @default.
• W2028238051 hasAuthorship W2028238051A5007833163 @default.
• W2028238051 hasAuthorship W2028238051A5012154124 @default.
• W2028238051 hasAuthorship W2028238051A5014624716 @default.
• W2028238051 hasAuthorship W2028238051A5016037005 @default.
• W2028238051 hasAuthorship W2028238051A5020891630 @default.
• W2028238051 hasAuthorship W2028238051A5022441333 @default.
• W2028238051 hasAuthorship W2028238051A5022867637 @default.
• W2028238051 hasAuthorship W2028238051A5036112915 @default.
• W2028238051 hasAuthorship W2028238051A5041183761 @default.
• W2028238051 hasAuthorship W2028238051A5045519730 @default.
• W2028238051 hasAuthorship W2028238051A5048682080 @default.
• W2028238051 hasAuthorship W2028238051A5054605942 @default.
• W2028238051 hasAuthorship W2028238051A5064116200 @default.
• W2028238051 hasAuthorship W2028238051A5067425596 @default.
• W2028238051 hasAuthorship W2028238051A5069302574 @default.
• W2028238051 hasAuthorship W2028238051A5075227924 @default.
• W2028238051 hasAuthorship W2028238051A5078714130 @default.
• W2028238051 hasConcept C126322002 @default.
• W2028238051 hasConcept C159047783 @default.
• W2028238051 hasConcept C159654299 @default.
• W2028238051 hasConcept C203014093 @default.
• W2028238051 hasConcept C22070199 @default.
• W2028238051 hasConcept C2522874641 @default.
• W2028238051 hasConcept C2777546802 @default.
• W2028238051 hasConcept C2777863537 @default.
• W2028238051 hasConcept C2779134260 @default.
• W2028238051 hasConcept C2780689484 @default.
• W2028238051 hasConcept C2780868878 @default.
• W2028238051 hasConcept C3008058167 @default.
• W2028238051 hasConcept C519248777 @default.
• W2028238051 hasConcept C524204448 @default.
• W2028238051 hasConcept C71924100 @default.
• W2028238051 hasConcept C89623803 @default.
• W2028238051 hasConceptScore W2028238051C126322002 @default.
• W2028238051 hasConceptScore W2028238051C159047783 @default.
• W2028238051 hasConceptScore W2028238051C159654299 @default.
• W2028238051 hasConceptScore W2028238051C203014093 @default.
• W2028238051 hasConceptScore W2028238051C22070199 @default.
• W2028238051 hasConceptScore W2028238051C2522874641 @default.
• W2028238051 hasConceptScore W2028238051C2777546802 @default.
• W2028238051 hasConceptScore W2028238051C2777863537 @default.
• W2028238051 hasConceptScore W2028238051C2779134260 @default.

• next