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- W2028248834 abstract "The volumetric mass transfer coefficient kLa is a very important parameter that plays an important role in bioreactor design. Numerous authors have reported that the use of simple models not taking into account the dispersion effects in the gas and/or liquid phase may cause a large error in kLa estimation. We have analysed the effect of another factor on kLa determination, namely, the effect of the pressure profile along the vessel height. We propose a two-phase dispersion model which takes into account the pressure profile. We studied the sensitivity of various parameters to error caused by neglecting the pressure profile. It was found that even when applying an experimental technique that eliminates dispersion effects, the existence of the pressure profile needs to be taken into account, especially in large volume tanks with a non-ideal flow pattern in the liquid phase. We propose a simple correlation describing the error caused by neglecting the pressure profile. The proposed procedure can be used to correct all mass transfer coefficients evaluated by a model not taking into account the pressure profile." @default.
- W2028248834 created "2016-06-24" @default.
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- W2028248834 date "2000-04-01" @default.
- W2028248834 modified "2023-09-26" @default.
- W2028248834 title "Effect of pressure profile on evaluation of volumetric mass transfer coefficient in ka bioreactors" @default.
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- W2028248834 doi "https://doi.org/10.1016/s1369-703x(99)00063-7" @default.
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