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• W2028251782 endingPage "164" @default.
• W2028251782 startingPage "158" @default.
• W2028251782 abstract "The compound 2-methoxy-1,4-naphthoquinone (MNQ) was previously shown to be cytotoxic against several cancer cell lines, but its mode of action is poorly understood. In this study, we aimed to explore the molecular mechanism of MNQ-induced cytotoxicity of A549 lung adenocarcinoma cells. The growth inhibition potential of MNQ was analyzed using sulforhodamine B assay, flow cytometry cell cycle analysis and Annexin V apoptosis assay. Oxidative stress was determined using 2′,7′-dichlorofluorescein diacetate to measure intracellular reactive oxygen species level and comet assay to measure DNA damage. Western blotting was performed to study the activation of mitogen-activated protein kinase signaling pathways. MNQ induced apoptosis of A549 cells independent of cell cycle arrest, and is mediated by the JNK and p38 MAPK signaling pathways. Further analysis demonstrated that these signaling pathways were stimulated by oxidative DNA damage caused by increased ROS generation in MNQ-treated A549 cells. This study is the first to provide an insight into the molecular mechanism of MNQ-induced cytotoxicity of a lung cancer cell, which demonstrates the potential of MNQ as a potential chemotherapeutic drug for lung cancer treatment." @default.
• W2028251782 created "2016-06-24" @default.
• W2028251782 creator A5011311529 @default.
• W2028251782 creator A5019172467 @default.
• W2028251782 creator A5052698344 @default.
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• W2028251782 date "2015-08-01" @default.
• W2028251782 modified "2023-10-14" @default.
• W2028251782 title "2-Methoxy-1,4-naphthoquinone (MNQ) induces apoptosis of A549 lung adenocarcinoma cells via oxidation-triggered JNK and p38 MAPK signaling pathways" @default.
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• W2028251782 doi "https://doi.org/10.1016/j.lfs.2015.03.019" @default.
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• W2028251782 hasPublicationYear "2015" @default.
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