Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028256918> ?p ?o ?g. }
- W2028256918 endingPage "15441" @default.
- W2028256918 startingPage "15436" @default.
- W2028256918 abstract "The mechanisms that regulate hematopoietic stem cell (HSC) fate decisions between proliferation and multilineage differentiation are unclear. Members of the Wnt family of ligands that activate the canonical Wnt signaling pathway, which utilizes β-catenin to relay the signal, have been demonstrated to regulate HSC function. In this study, we examined the role of noncanonical Wnt signaling in regulating HSC fate. We observed that noncanonical Wnt5a inhibited Wnt3a-mediated canonical Wnt signaling in HSCs and suppressed Wnt3a-mediated alterations in gene expression associated with HSC differentiation, such as increased expression of myc . Wnt5a increased short- and long-term HSC repopulation by maintaining HSCs in a quiescent G 0 state. From these data, we propose that Wnt5a regulates hematopoiesis by the antagonism of the canonical Wnt pathway, resulting in a pool of quiescent HSCs." @default.
- W2028256918 created "2016-06-24" @default.
- W2028256918 creator A5016326637 @default.
- W2028256918 creator A5038836803 @default.
- W2028256918 creator A5046244490 @default.
- W2028256918 creator A5048397569 @default.
- W2028256918 creator A5079669538 @default.
- W2028256918 date "2007-09-25" @default.
- W2028256918 modified "2023-10-18" @default.
- W2028256918 title "Wnt5a inhibits canonical Wnt signaling in hematopoietic stem cells and enhances repopulation" @default.
- W2028256918 cites W129269179 @default.
- W2028256918 cites W1484778901 @default.
- W2028256918 cites W1816761971 @default.
- W2028256918 cites W189173739 @default.
- W2028256918 cites W1989456936 @default.
- W2028256918 cites W1993683417 @default.
- W2028256918 cites W2009684443 @default.
- W2028256918 cites W2012962381 @default.
- W2028256918 cites W2023192965 @default.
- W2028256918 cites W2031321792 @default.
- W2028256918 cites W2038672919 @default.
- W2028256918 cites W2039971323 @default.
- W2028256918 cites W2042188178 @default.
- W2028256918 cites W2043474049 @default.
- W2028256918 cites W2050222325 @default.
- W2028256918 cites W2059915932 @default.
- W2028256918 cites W2060300682 @default.
- W2028256918 cites W2066277278 @default.
- W2028256918 cites W2071397057 @default.
- W2028256918 cites W2073838144 @default.
- W2028256918 cites W2083257994 @default.
- W2028256918 cites W2103054294 @default.
- W2028256918 cites W2104989755 @default.
- W2028256918 cites W2107106369 @default.
- W2028256918 cites W2118453722 @default.
- W2028256918 cites W2119284420 @default.
- W2028256918 cites W2119704135 @default.
- W2028256918 cites W2121878535 @default.
- W2028256918 cites W2134195865 @default.
- W2028256918 cites W2147257521 @default.
- W2028256918 cites W2147864074 @default.
- W2028256918 cites W2150902176 @default.
- W2028256918 cites W2152414109 @default.
- W2028256918 cites W2154041910 @default.
- W2028256918 cites W2155348369 @default.
- W2028256918 cites W2155507705 @default.
- W2028256918 cites W2247574020 @default.
- W2028256918 cites W2336183884 @default.
- W2028256918 cites W4237567990 @default.
- W2028256918 cites W4238258622 @default.
- W2028256918 cites W4241228599 @default.
- W2028256918 cites W4252585262 @default.
- W2028256918 doi "https://doi.org/10.1073/pnas.0704747104" @default.
- W2028256918 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1986571" @default.
- W2028256918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17881570" @default.
- W2028256918 hasPublicationYear "2007" @default.
- W2028256918 type Work @default.
- W2028256918 sameAs 2028256918 @default.
- W2028256918 citedByCount "270" @default.
- W2028256918 countsByYear W20282569182012 @default.
- W2028256918 countsByYear W20282569182013 @default.
- W2028256918 countsByYear W20282569182014 @default.
- W2028256918 countsByYear W20282569182015 @default.
- W2028256918 countsByYear W20282569182016 @default.
- W2028256918 countsByYear W20282569182017 @default.
- W2028256918 countsByYear W20282569182018 @default.
- W2028256918 countsByYear W20282569182019 @default.
- W2028256918 countsByYear W20282569182020 @default.
- W2028256918 countsByYear W20282569182021 @default.
- W2028256918 countsByYear W20282569182022 @default.
- W2028256918 countsByYear W20282569182023 @default.
- W2028256918 crossrefType "journal-article" @default.
- W2028256918 hasAuthorship W2028256918A5016326637 @default.
- W2028256918 hasAuthorship W2028256918A5038836803 @default.
- W2028256918 hasAuthorship W2028256918A5046244490 @default.
- W2028256918 hasAuthorship W2028256918A5048397569 @default.
- W2028256918 hasAuthorship W2028256918A5079669538 @default.
- W2028256918 hasBestOaLocation W20282569181 @default.
- W2028256918 hasConcept C104317684 @default.
- W2028256918 hasConcept C109159458 @default.
- W2028256918 hasConcept C137620995 @default.
- W2028256918 hasConcept C163952510 @default.
- W2028256918 hasConcept C170320316 @default.
- W2028256918 hasConcept C182819311 @default.
- W2028256918 hasConcept C2778086970 @default.
- W2028256918 hasConcept C2779131293 @default.
- W2028256918 hasConcept C2779324961 @default.
- W2028256918 hasConcept C2780176071 @default.
- W2028256918 hasConcept C28328180 @default.
- W2028256918 hasConcept C54355233 @default.
- W2028256918 hasConcept C62478195 @default.
- W2028256918 hasConcept C86339819 @default.
- W2028256918 hasConcept C86803240 @default.
- W2028256918 hasConcept C95444343 @default.
- W2028256918 hasConceptScore W2028256918C104317684 @default.
- W2028256918 hasConceptScore W2028256918C109159458 @default.
- W2028256918 hasConceptScore W2028256918C137620995 @default.
- W2028256918 hasConceptScore W2028256918C163952510 @default.