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- W2028256961 abstract "The Cell Biology Symposium titled “Novel technologies and novel insights” was held at the Joint Annual Meeting of the American Society of Animal Science and the American Dairy Science Association in New Orleans, Louisiana, July 10 to 14, 2011. The purpose of the symposium was to provide the animal science community with an update on novel molecular technologies that allow new insights into genome structure and function in livestock. The first speaker of the symposium, Jeffrey Whyte (University of Missouri, Columbia), provided an overview of conventional and emerging technologies to modify the genome in mammals with specific examples in swine (Whyte and Prather, 2011). Engineered zinc finger nucleases (ZFN) have recently been developed that bind and cleave DNA at specific sequences and lead to targeting efficiencies up to 10,000-fold greater than conventional gene targeting methods with somatic cell nuclear transfer. The ZFN technology provides a precise mechanism to either disrupt a gene coding sequence (i.e., gene knockout) or enhance insertion of a DNA construct (i.e., transgenesis or gene knock-in). Several laboratories have now used ZFN technology to knockout genes in the swine genome. Availability of the draft swine genome sequence in combination with ZFN technology to modify the swine genome should allow more rapid and efficient development of swine models for the dual benefit of agricultural and biomedical research." @default.
- W2028256961 created "2016-06-24" @default.
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- W2028256961 date "2012-04-01" @default.
- W2028256961 modified "2023-10-17" @default.
- W2028256961 title "CELL BIOLOGY SYMPOSIUM: Novel technologies and novel insights1" @default.
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- W2028256961 doi "https://doi.org/10.2527/jas.2012-5086" @default.
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