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• W2028257890 startingPage "1017" @default.
• W2028257890 abstract "We present a computational study of barnase unfolding during import into mitochondria through a model translocon. In contrast to thermal (or chemical) unfolding, the major intermediates of co-translocational unfolding are mainly mediated by non-native interactions accompanying the protein configurations induced by pulling forces. These energy contributions, combined with backbone topological constraints imposed by the model pore, result in milestones along the unfolding pathways which are significantly different not only from those experienced during thermal (or chemical) denaturation, but also from those observed in single-molecule pulling by both ends without pore constraints. Two on-pathway major translocation intermediates trapped in long-lived states by significantly high unfolding barriers are identified. A fraction of these pathways can, however, skip such local kinetic traps and result in extremely fast translocations, leading to a dramatic kinetic partitioning spanning approximately four orders of magnitude. The fraction of fast translocation events is shown to increase upon switching the pull off and on, when compared to pulling at constant force. This suggests a catalytic mechanism by which the mitochondrial import machinery regulates this partitioning by repetitively pulling in cycles. A number of mutation sites that alter the kinetic flow of the unfolding trajectories are suggested and tested." @default.
• W2028257890 created "2016-06-24" @default.
• W2028257890 creator A5058565205 @default.
• W2028257890 creator A5085371660 @default.
• W2028257890 date "2005-07-01" @default.
• W2028257890 modified "2023-09-27" @default.
• W2028257890 title "Repetitive Pulling Catalyzes Co-translocational Unfolding of Barnase During Import Through a Mitochondrial Pore" @default.
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• W2028257890 doi "https://doi.org/10.1016/j.jmb.2005.05.035" @default.
• W2028257890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15979642" @default.
• W2028257890 hasPublicationYear "2005" @default.
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