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• W2028259923 startingPage "881" @default.
• W2028259923 abstract "Cadherins are crucial for tissue cohesion, separation of cell layers and cell migration during embryogenesis. To investigate the role of classical type II Xcadherin-6 (Xcad-6), we performed loss-of-function studies by morpholino oligonucleotide injections. This resulted in severe eye defects which could be rescued with murine cadherin-6. In the absence of Xcadherin-6, morphological alterations and a decrease in cell proliferation were observed with eye cup formation. Eye field transplantations of Xcadherin-6 depleted donors yielded grafts that failed to form a proper neuroepithelium in a wildtype environment. At later developmental stages Xcadherin-6 deficient eyes showed lamination defects in the outer neural retina, a reduced thickness of the ganglion cell layer (GCL) and a fragmented retina pigment epithelium (RPE). Thus, Xcadherin-6 is essential early in eye development for structural organization and growth of the neuroepithelium before it differentiates into neural retina and RPE." @default.
• W2028259923 created "2016-06-24" @default.
• W2028259923 creator A5038545409 @default.
• W2028259923 creator A5052358604 @default.
• W2028259923 creator A5075741701 @default.
• W2028259923 date "2006-12-01" @default.
• W2028259923 modified "2023-10-17" @default.
• W2028259923 title "Xenopus cadherin-6 regulates growth and epithelial development of the retina" @default.
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• W2028259923 doi "https://doi.org/10.1016/j.mod.2006.08.010" @default.
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