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• W2028264909 abstract "We reported previously that balneotherapy using Kusatsu hot-spring water is useful for controlling the skin symptoms of acute flares/exacerbations of refractory cases of atopic dermatitis. As Staphylococcus aureus on the skin surface decreased in number or disappeared after balneotherapy, the hot-spring water was suspected to act against the microorganism. The hot-spring water showed strong bactericidal activity against S. aureus in vitro. In order to clarify the mechanism further, the bactericidal activity of the hot-spring water was examined by adding back cations and anions in same concentrations as those in the original hot-spring water, one at a time to cation- and anion-exchanged hot-spring water. The findings clearly demonstrated that the bactericidal activity was expressed by manganese and iodide ions in acidic conditions (pH 2.0-3.0). Thus, the probable mechanism for the improvement of skin manifestations through Kusatsu balneotherapy is the bactericidal activity of the hot-spring water against S. aureus. When added to water acidified with sulphuric acid (pH 2.0-3.0) a synergistic effect of the 2 ions was observed, so that an anti-staphylococcal effect was obtained even at low concentrations (1 mg/kg). Acidic solutions containing manganese and iodide ions may thus be clinically useful for treating skin conditions caused by S. aureus." @default.
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• W2028264909 date "1999-08-11" @default.
• W2028264909 modified "2023-10-09" @default.
• W2028264909 title "Bactericidal Activity of Manganese and Iodide Ions against Staphylococcus aureus: A Possible Treatment for Acute Atopic Dermatitis" @default.
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• W2028264909 doi "https://doi.org/10.1080/000155599750010265" @default.
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