Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028282498> ?p ?o ?g. }
- W2028282498 endingPage "195" @default.
- W2028282498 startingPage "186" @default.
- W2028282498 abstract "Primary radiotherapy (RT) is a mainstay of treatment for laryngeal squamous cell carcinoma (LSCC). Although the cure rates for early (T1) vocal cord tumours are high, RT proves ineffective in up to a third of T3 carcinomas. Moreover, RT is associated with debilitating early- and late-treatment-related toxicity, thus finding means to de-escalate therapy, while retaining/augmenting therapeutic effectiveness, is highly desirable. p53 is a key mediator of radiation responses; we therefore investigated whether Nutlin-3, a small-molecule inhibitor of MDM2 (mouse double minute 2; an essential negative regulator of p53), might radiosensitise LSCC cells. We performed clonogenic assays to measure radiosensitivity in a panel of LSCC cell lines (for which we determined p53 mutational status) in the presence and absence of Nutlin-3. LSCC cells harbouring wild-type p53 were significantly radiosensitised by Nutlin-3 (P<0.0001; log-rank scale), and displayed increased cell cycle arrest and significantly increased senescence (P<0.001) in the absence of increased apoptosis; thus, our data suggest that senescence may mediate this increased radiosensitivity. This is the first study showing Nutlin-3 as an effective radiosensitiser in LSCC cells that retain wild-type p53. The clinical application of Nutlin-3 might improve local recurrence rates or allow treatment de-escalation in these patients." @default.
- W2028282498 created "2016-06-24" @default.
- W2028282498 creator A5001659943 @default.
- W2028282498 creator A5007808467 @default.
- W2028282498 creator A5014290613 @default.
- W2028282498 creator A5015598258 @default.
- W2028282498 creator A5026466090 @default.
- W2028282498 creator A5026829366 @default.
- W2028282498 creator A5035282849 @default.
- W2028282498 creator A5064916439 @default.
- W2028282498 creator A5065417359 @default.
- W2028282498 creator A5070059734 @default.
- W2028282498 creator A5078336910 @default.
- W2028282498 creator A5087858455 @default.
- W2028282498 date "2010-06-29" @default.
- W2028282498 modified "2023-10-07" @default.
- W2028282498 title "Nutlin-3, the small-molecule inhibitor of MDM2, promotes senescence and radiosensitises laryngeal carcinoma cells harbouring wild-type p53" @default.
- W2028282498 cites W1912423223 @default.
- W2028282498 cites W1970101659 @default.
- W2028282498 cites W1975078971 @default.
- W2028282498 cites W1976261939 @default.
- W2028282498 cites W1976873804 @default.
- W2028282498 cites W1981299193 @default.
- W2028282498 cites W1981979392 @default.
- W2028282498 cites W1990431346 @default.
- W2028282498 cites W1993263392 @default.
- W2028282498 cites W1993278073 @default.
- W2028282498 cites W1994505979 @default.
- W2028282498 cites W1996632098 @default.
- W2028282498 cites W2008257691 @default.
- W2028282498 cites W2014563476 @default.
- W2028282498 cites W2018651892 @default.
- W2028282498 cites W2020830322 @default.
- W2028282498 cites W2024604828 @default.
- W2028282498 cites W2025476423 @default.
- W2028282498 cites W2038905802 @default.
- W2028282498 cites W2040881358 @default.
- W2028282498 cites W2041444090 @default.
- W2028282498 cites W2042923408 @default.
- W2028282498 cites W2047242201 @default.
- W2028282498 cites W2049304197 @default.
- W2028282498 cites W2073576377 @default.
- W2028282498 cites W2076272592 @default.
- W2028282498 cites W2077423253 @default.
- W2028282498 cites W2097933346 @default.
- W2028282498 cites W2100494757 @default.
- W2028282498 cites W2104908670 @default.
- W2028282498 cites W2108031205 @default.
- W2028282498 cites W2113670871 @default.
- W2028282498 cites W2147777207 @default.
- W2028282498 cites W2154745425 @default.
- W2028282498 cites W2157459126 @default.
- W2028282498 cites W2161379087 @default.
- W2028282498 cites W2163186602 @default.
- W2028282498 cites W2166406736 @default.
- W2028282498 cites W2167270041 @default.
- W2028282498 cites W2170494099 @default.
- W2028282498 cites W2397257832 @default.
- W2028282498 cites W2504155943 @default.
- W2028282498 doi "https://doi.org/10.1038/sj.bjc.6605739" @default.
- W2028282498 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2906734" @default.
- W2028282498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20588277" @default.
- W2028282498 hasPublicationYear "2010" @default.
- W2028282498 type Work @default.
- W2028282498 sameAs 2028282498 @default.
- W2028282498 citedByCount "49" @default.
- W2028282498 countsByYear W20282824982012 @default.
- W2028282498 countsByYear W20282824982013 @default.
- W2028282498 countsByYear W20282824982014 @default.
- W2028282498 countsByYear W20282824982015 @default.
- W2028282498 countsByYear W20282824982016 @default.
- W2028282498 countsByYear W20282824982017 @default.
- W2028282498 countsByYear W20282824982018 @default.
- W2028282498 countsByYear W20282824982019 @default.
- W2028282498 countsByYear W20282824982020 @default.
- W2028282498 countsByYear W20282824982021 @default.
- W2028282498 countsByYear W20282824982022 @default.
- W2028282498 countsByYear W20282824982023 @default.
- W2028282498 crossrefType "journal-article" @default.
- W2028282498 hasAuthorship W2028282498A5001659943 @default.
- W2028282498 hasAuthorship W2028282498A5007808467 @default.
- W2028282498 hasAuthorship W2028282498A5014290613 @default.
- W2028282498 hasAuthorship W2028282498A5015598258 @default.
- W2028282498 hasAuthorship W2028282498A5026466090 @default.
- W2028282498 hasAuthorship W2028282498A5026829366 @default.
- W2028282498 hasAuthorship W2028282498A5035282849 @default.
- W2028282498 hasAuthorship W2028282498A5064916439 @default.
- W2028282498 hasAuthorship W2028282498A5065417359 @default.
- W2028282498 hasAuthorship W2028282498A5070059734 @default.
- W2028282498 hasAuthorship W2028282498A5078336910 @default.
- W2028282498 hasAuthorship W2028282498A5087858455 @default.
- W2028282498 hasBestOaLocation W20282824981 @default.
- W2028282498 hasConcept C104317684 @default.
- W2028282498 hasConcept C105696609 @default.
- W2028282498 hasConcept C117262875 @default.
- W2028282498 hasConcept C126322002 @default.
- W2028282498 hasConcept C143065580 @default.
- W2028282498 hasConcept C143998085 @default.