FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028286814> ?p ?o ?g. }

• W2028286814 endingPage "98" @default.
• W2028286814 startingPage "91" @default.
• W2028286814 abstract "The effects of surfactant, surfactant lipids, and surfactant protein A (SP-A) on the surface phagocytosis of [3H]thymidine-labeled Staphylococcus aureus (SAE) by rat alveolar macrophages were studied. Alveolar macrophages only ingest SAE when the bacteria are opsonized with rat serum prior to incubation with alveolar macrophages. Preincubation or “opsonization” of the bacteria with surfactant did not result in phagocytosis by the macrophages. However, preincubation of the macrophages with surfactant increased the phagocytosis of rat serum-opsonized bacteria by approximately 70% when compared to the control macrophages. The factor present in surfactant causing the stimulation of the phagocytosis is probably SP-A. Preincubation of macrophages with human SP-A enhanced the phagocytosis to the same extent as whole surfactant, whereas preincubation with surfactant lipids had no effect on the phagocytosis. The SP-A-induced enhancement of the phagocytosis is time, temperature, and concentration dependent. Phagocytosis of opsonized SAE by alveolar macrophages was maximal after 15 min of incubation and at an SP-A concentration of 1 µg/ml. No phagocytosis occurred at 0° C.In addition, whole surfactant and SP-A induce a lucigenin-dependent chemiluminescence response in alveolar macrophages. The chemiluminescence response is initiated after 15 min of incubation and reaches a maximum after 30 min. The concentration of SP-A needed for an optimal response is in the same order of magnitude as the concentration needed for maximal enhancement of the phagocytosis of SAE by alveolar macrophages. The chemiluminescence response of alveolar macrophages incubated with SP-A and SAE together equals the sum of the responses of alveolar macrophages incubated with SP-A and SAE separately. This may indicate that SP-A and SAE act cooperatively in the generation of a chemiluminescence response by alveolar macrophages.The SP-A-induced response appears to be specific for alveolar macrophages, as peritoneal macrophages, polymorphonuclear leukocytes, and monocytes cannot be elicited by SP-A. This study demonstrates that SP-A potentiates the antibacterial functions of alveolar macrophages." @default.
• W2028286814 created "2016-06-24" @default.
• W2028286814 creator A5004817782 @default.
• W2028286814 creator A5009099757 @default.
• W2028286814 creator A5030530700 @default.
• W2028286814 creator A5042121840 @default.
• W2028286814 creator A5068609020 @default.
• W2028286814 date "1990-01-01" @default.
• W2028286814 modified "2023-09-26" @default.
• W2028286814 title "Pulmonary Surfactant Protein A Enhances the Host-defense Mechanism of Rat Alveolar Macrophages" @default.
• W2028286814 cites W1513897103 @default.
• W2028286814 cites W1560807874 @default.
• W2028286814 cites W1591127773 @default.
• W2028286814 cites W1607610170 @default.
• W2028286814 cites W1857130763 @default.
• W2028286814 cites W1944789074 @default.
• W2028286814 cites W1965321622 @default.
• W2028286814 cites W1965996955 @default.
• W2028286814 cites W1974242613 @default.
• W2028286814 cites W1991848019 @default.
• W2028286814 cites W1994716115 @default.
• W2028286814 cites W2018941038 @default.
• W2028286814 cites W2032922952 @default.
• W2028286814 cites W2072185681 @default.
• W2028286814 cites W2087095342 @default.
• W2028286814 cites W2115910210 @default.
• W2028286814 cites W2119084781 @default.
• W2028286814 cites W2145217440 @default.
• W2028286814 cites W2152311269 @default.
• W2028286814 cites W2164068257 @default.
• W2028286814 cites W2182132278 @default.
• W2028286814 cites W2188958959 @default.
• W2028286814 cites W2468119228 @default.
• W2028286814 cites W305416848 @default.
• W2028286814 doi "https://doi.org/10.1165/ajrcmb/2.1.91" @default.
• W2028286814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2306370" @default.
• W2028286814 hasPublicationYear "1990" @default.
• W2028286814 type Work @default.
• W2028286814 sameAs 2028286814 @default.
• W2028286814 citedByCount "357" @default.
• W2028286814 countsByYear W20282868142012 @default.
• W2028286814 countsByYear W20282868142013 @default.
• W2028286814 countsByYear W20282868142014 @default.
• W2028286814 countsByYear W20282868142015 @default.
• W2028286814 countsByYear W20282868142016 @default.
• W2028286814 countsByYear W20282868142017 @default.
• W2028286814 countsByYear W20282868142018 @default.
• W2028286814 countsByYear W20282868142020 @default.
• W2028286814 countsByYear W20282868142021 @default.
• W2028286814 countsByYear W20282868142022 @default.
• W2028286814 countsByYear W20282868142023 @default.
• W2028286814 crossrefType "journal-article" @default.
• W2028286814 hasAuthorship W2028286814A5004817782 @default.
• W2028286814 hasAuthorship W2028286814A5009099757 @default.
• W2028286814 hasAuthorship W2028286814A5030530700 @default.
• W2028286814 hasAuthorship W2028286814A5042121840 @default.
• W2028286814 hasAuthorship W2028286814A5068609020 @default.
• W2028286814 hasConcept C136449434 @default.
• W2028286814 hasConcept C160448771 @default.
• W2028286814 hasConcept C168507396 @default.
• W2028286814 hasConcept C170493617 @default.
• W2028286814 hasConcept C185592680 @default.
• W2028286814 hasConcept C194108754 @default.
• W2028286814 hasConcept C202751555 @default.
• W2028286814 hasConcept C25642318 @default.
• W2028286814 hasConcept C2777438239 @default.
• W2028286814 hasConcept C2778012055 @default.
• W2028286814 hasConcept C2778543330 @default.
• W2028286814 hasConcept C2778870864 @default.
• W2028286814 hasConcept C2779244956 @default.
• W2028286814 hasConcept C55493867 @default.
• W2028286814 hasConcept C58226133 @default.
• W2028286814 hasConcept C86803240 @default.
• W2028286814 hasConcept C89372155 @default.
• W2028286814 hasConcept C89423630 @default.
• W2028286814 hasConceptScore W2028286814C136449434 @default.
• W2028286814 hasConceptScore W2028286814C160448771 @default.
• W2028286814 hasConceptScore W2028286814C168507396 @default.
• W2028286814 hasConceptScore W2028286814C170493617 @default.
• W2028286814 hasConceptScore W2028286814C185592680 @default.
• W2028286814 hasConceptScore W2028286814C194108754 @default.
• W2028286814 hasConceptScore W2028286814C202751555 @default.
• W2028286814 hasConceptScore W2028286814C25642318 @default.
• W2028286814 hasConceptScore W2028286814C2777438239 @default.
• W2028286814 hasConceptScore W2028286814C2778012055 @default.
• W2028286814 hasConceptScore W2028286814C2778543330 @default.
• W2028286814 hasConceptScore W2028286814C2778870864 @default.
• W2028286814 hasConceptScore W2028286814C2779244956 @default.
• W2028286814 hasConceptScore W2028286814C55493867 @default.
• W2028286814 hasConceptScore W2028286814C58226133 @default.
• W2028286814 hasConceptScore W2028286814C86803240 @default.
• W2028286814 hasConceptScore W2028286814C89372155 @default.
• W2028286814 hasConceptScore W2028286814C89423630 @default.
• W2028286814 hasIssue "1" @default.
• W2028286814 hasLocation W20282868141 @default.
• W2028286814 hasLocation W20282868142 @default.
• W2028286814 hasOpenAccess W2028286814 @default.
• W2028286814 hasPrimaryLocation W20282868141 @default.

• next