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• W2028291236 abstract "No AccessJournal of UrologyInvestigative Urology1 Dec 2005FLUORESCENCE GUIDED OPTICAL COHERENCE TOMOGRAPHY FOR THE DIAGNOSIS OF EARLY BLADDER CANCER IN A RAT MODEL Z.G. WANG, D.B. DURAND, M. SCHOENBERG, and Y.T. PAN Z.G. WANGZ.G. WANG More articles by this author , D.B. DURANDD.B. DURAND More articles by this author , M. SCHOENBERGM. SCHOENBERG More articles by this author , and Y.T. PANY.T. PAN More articles by this author View All Author Informationhttps://doi.org/10.1097/01.ju.0000180413.98752.a1AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We describe the technique of fluorescence image guided optical coherence tomography (FG-OCT). We examined its ability to enhance specificity and sensitivity for the noninvasive diagnosis of early bladder cancer. Materials and Methods: Transitional cell carcinoma was developed in 54 Fisher 344 female rats by intravesical methyl-nitroso-urea instillations. Two or three rats were diagnosed sequentially by 5-ALA (5-aminolevulinic acid hydrochloride) induced fluorescence imaging, cross-sectional OCT and histological microscopy weekly during weeks 11 to 33 following initial methyl-nitroso-urea instillation to track the course of carcinogenesis. Results: The specificity of fluorescence detection was significantly enhanced by FG-OCT (53% and 93%, respectively, p <0.0001). The sensitivity of fluorescence detection and FG-OCT was 79% and 100%, respectively. Conclusions: FG-OCT cystoscopy has the potential to diagnose early bladder cancer with high sensitivity and specificity with drastically decreased imaging time compared to that of white light guided OCT cystoscopy. 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Google Scholar From the Departments of Biomedical Engineering (ZGW, YTP) and Pathology (DBD), State University of New York at Stony Brook, Stony Brook, New York, and Department of Urology, John Hopkins University (MS), Baltimore, Maryland© 2005 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byRen H, Park K, Pan R, Waltzer W, Shroyer K and Pan Y (2012) Early Detection of Carcinoma In Situ of the Bladder: A Comparative Study of White Light Cystoscopy, Narrow Band Imaging, 5-ALA Fluorescence Cystoscopy and 3-Dimensional Optical Coherence TomographyJournal of Urology, VOL. 187, NO. 3, (1063-1070), Online publication date: 1-Mar-2012.Ren H, Yuan Z, Waltzer W, Shroyer K and Pan Y (2010) Enhancing Detection of Bladder Carcinoma In Situ by 3-Dimensional Optical Coherence TomographyJournal of Urology, VOL. 184, NO. 4, (1499-1506), Online publication date: 1-Oct-2010. Volume 174Issue 6December 2005Page: 2376-2381 Advertisement Copyright & Permissions© 2005 by American Urological Association, Inc.Keywordsrats, inbred F344tomography, optical coherencecarcinoma, transitional cellbladder neoplasmsbladderMetricsAuthor Information Z.G. WANG More articles by this author D.B. DURAND More articles by this author M. SCHOENBERG More articles by this author Y.T. PAN More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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