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- W2028291862 abstract "Neutral endopeptidase (NEP), angiotensin-converting enzyme (ACE), and aminopeptidase N (APN) are involved in the metabolism of several regulatory peptides of human nervous, cardiovascular, inflammatory and immune systems. A new class of dual metallopeptidase inhibitors of ACE and NEP (vasopeptidase inhibitors), are found more effective than monotherapy with either inhibitors of ACE or of NEP in the treatment of cardiovascular diseases [1, 2]. In addition NEP inhibitors such as thiorphan have found active as antidiarrheal agent [3, 4]. APN inhibitors as well as dual APN/NEP inhibitors are other targets of scientific research to develop anticancer and anti-inflammatory drugs as well as a new class of analgesic and antidepressant drugs respectively [5, 6]. The purpose of our study was to screen 15 extracts of different polarities from 5 Yemeni medicinal plants (Aspilia helianthoides, Ceropegia rupicola, Kniphofia sumarae, Pavetta longiflora, Plectranthus cf. barbatus) for inhibitory effect against NEP, ACE and APN activities. A series of concentrations (1, 10, 25, 50, 100, and 200µg/ml) of each extract were tested. 4 extracts (methanol extracts of Ceropegia rupicola, Kniphofia sumarae, and Plectranthus cf. barbatus, and the aqueous extract of Pavetta longiflora) were found to inhibit the enzymatic activity of NEP. The most active extract was the methanolic extract of Ceropegia rupicola with IC50=111µg/ml. Only the methanolic extract of Aspilia helianthoides was found to exhibit inhibitory effect against the ACE activity. None of the tested plant extracts was found active against the aminopeptidase N activity." @default.
- W2028291862 created "2016-06-24" @default.
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- W2028291862 date "2008-01-01" @default.
- W2028291862 modified "2023-10-18" @default.
- W2028291862 title "Screening of some Yemeni medicinal plants for inhibitory activity against peptidases" @default.
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- W2028291862 doi "https://doi.org/10.1055/s-2008-1047849" @default.
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