FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028294428> ?p ?o ?g. }

• W2028294428 endingPage "148" @default.
• W2028294428 startingPage "143" @default.
• W2028294428 abstract "Several investigators have reported that inactivation of secretory phospholipase A2 purified from bee venom with p-bromophenacyl bromide, an irreversible inhibitor, before injection resulted in attenuation of the subsequent inflammatory reaction in the mouse paw edema model. Recently, thielocin A1 beta, a novel secretory phospholipase A2 inhibitor from fungi, was found to suppress histamine release from mast cells stimulated with secretory phospholipase A2. These observations led us to examine the effect of thielocin A1 beta against secretory phospholipase A2-induced paw edema. Thielocin A1 beta inhibited bee venom phospholipase A2 in a dose-dependent manner (IC50 = 1.4 microM). In addition, the inhibition of bee venom phospholipase A2 was noncompetitive (Ki = 0.57 microM) and reversible. Subplantar injection of bee venom phospholipase A2 produced a rapid but transient edematous response. Coinjection of thielocin A1 beta (1 microgram/paw) with bee venom phospholipase A2 resulted in a 44.7 +/- 4.6% reduction of edema formation. This anti-edema action was not enhanced by cyproheptadine (antihistamine/antiserotonin). These results suggest that thielocin A1 beta shows edema-reducing activity via inhibition of the phospholipase A2 activity which participates in histamine release by mast cells." @default.
• W2028294428 created "2016-06-24" @default.
• W2028294428 creator A5019797971 @default.
• W2028294428 creator A5020289042 @default.
• W2028294428 creator A5045616690 @default.
• W2028294428 creator A5053312419 @default.
• W2028294428 date "1995-06-01" @default.
• W2028294428 modified "2023-09-26" @default.
• W2028294428 title "Effect of thielocin A1β on bee venom phospholipase A2-induced edema in mouse paw" @default.
• W2028294428 cites W1482693857 @default.
• W2028294428 cites W1488974291 @default.
• W2028294428 cites W1600965850 @default.
• W2028294428 cites W1790925641 @default.
• W2028294428 cites W1964814810 @default.
• W2028294428 cites W1978320676 @default.
• W2028294428 cites W1987056475 @default.
• W2028294428 cites W1991515499 @default.
• W2028294428 cites W1992458462 @default.
• W2028294428 cites W2008874973 @default.
• W2028294428 cites W2015871485 @default.
• W2028294428 cites W2016532072 @default.
• W2028294428 cites W2024101356 @default.
• W2028294428 cites W2045507648 @default.
• W2028294428 cites W2048775526 @default.
• W2028294428 cites W2059727135 @default.
• W2028294428 cites W2062750305 @default.
• W2028294428 cites W2076787563 @default.
• W2028294428 cites W2117562256 @default.
• W2028294428 cites W2138264815 @default.
• W2028294428 cites W2262061363 @default.
• W2028294428 cites W2325413306 @default.
• W2028294428 doi "https://doi.org/10.1016/0014-2999(95)00148-e" @default.
• W2028294428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7556394" @default.
• W2028294428 hasPublicationYear "1995" @default.
• W2028294428 type Work @default.
• W2028294428 sameAs 2028294428 @default.
• W2028294428 citedByCount "8" @default.
• W2028294428 countsByYear W20282944282021 @default.
• W2028294428 crossrefType "journal-article" @default.
• W2028294428 hasAuthorship W2028294428A5019797971 @default.
• W2028294428 hasAuthorship W2028294428A5020289042 @default.
• W2028294428 hasAuthorship W2028294428A5045616690 @default.
• W2028294428 hasAuthorship W2028294428A5053312419 @default.
• W2028294428 hasConcept C1122143 @default.
• W2028294428 hasConcept C126322002 @default.
• W2028294428 hasConcept C12927208 @default.
• W2028294428 hasConcept C170493617 @default.
• W2028294428 hasConcept C181199279 @default.
• W2028294428 hasConcept C185592680 @default.
• W2028294428 hasConcept C2775864247 @default.
• W2028294428 hasConcept C2776551241 @default.
• W2028294428 hasConcept C2776888444 @default.
• W2028294428 hasConcept C2778001312 @default.
• W2028294428 hasConcept C2778206117 @default.
• W2028294428 hasConcept C2779281246 @default.
• W2028294428 hasConcept C2779448229 @default.
• W2028294428 hasConcept C2780886150 @default.
• W2028294428 hasConcept C55493867 @default.
• W2028294428 hasConcept C71924100 @default.
• W2028294428 hasConcept C86803240 @default.
• W2028294428 hasConcept C98274493 @default.
• W2028294428 hasConceptScore W2028294428C1122143 @default.
• W2028294428 hasConceptScore W2028294428C126322002 @default.
• W2028294428 hasConceptScore W2028294428C12927208 @default.
• W2028294428 hasConceptScore W2028294428C170493617 @default.
• W2028294428 hasConceptScore W2028294428C181199279 @default.
• W2028294428 hasConceptScore W2028294428C185592680 @default.
• W2028294428 hasConceptScore W2028294428C2775864247 @default.
• W2028294428 hasConceptScore W2028294428C2776551241 @default.
• W2028294428 hasConceptScore W2028294428C2776888444 @default.
• W2028294428 hasConceptScore W2028294428C2778001312 @default.
• W2028294428 hasConceptScore W2028294428C2778206117 @default.
• W2028294428 hasConceptScore W2028294428C2779281246 @default.
• W2028294428 hasConceptScore W2028294428C2779448229 @default.
• W2028294428 hasConceptScore W2028294428C2780886150 @default.
• W2028294428 hasConceptScore W2028294428C55493867 @default.
• W2028294428 hasConceptScore W2028294428C71924100 @default.
• W2028294428 hasConceptScore W2028294428C86803240 @default.
• W2028294428 hasConceptScore W2028294428C98274493 @default.
• W2028294428 hasIssue "2-3" @default.
• W2028294428 hasLocation W20282944281 @default.
• W2028294428 hasLocation W20282944282 @default.
• W2028294428 hasOpenAccess W2028294428 @default.
• W2028294428 hasPrimaryLocation W20282944281 @default.
• W2028294428 hasRelatedWork W1973201032 @default.
• W2028294428 hasRelatedWork W1977846299 @default.
• W2028294428 hasRelatedWork W2019816897 @default.
• W2028294428 hasRelatedWork W2028294428 @default.
• W2028294428 hasRelatedWork W2029383168 @default.
• W2028294428 hasRelatedWork W2030302296 @default.
• W2028294428 hasRelatedWork W2093197487 @default.
• W2028294428 hasRelatedWork W2095562234 @default.
• W2028294428 hasRelatedWork W2098568521 @default.
• W2028294428 hasRelatedWork W2411562194 @default.
• W2028294428 hasVolume "279" @default.
• W2028294428 isParatext "false" @default.
• W2028294428 isRetracted "false" @default.
• W2028294428 magId "2028294428" @default.

• next