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- W2028294842 endingPage "1306" @default.
- W2028294842 startingPage "1292" @default.
- W2028294842 abstract "Urinary tract infections (UTI) are one of the most frequent extraintestinal infections caused by Escherichia coli (ExPEC). Cranberry juice has been used for decades to alleviate symptoms and prevent recurrent UTI. The putative compounds in cranberries are proanthocyanidins (PAC), specifically PAC with A-type bonds. Since PAC are not absorbed, their health benefits in UTI may occur through interactions at the mucosal surface in the gastrointestinal tract. Recent research showed that higher agglutination of ExPEC and reduced bacterial invasion are correlated with higher number of A-type bonds and higher degree of polymerization of PAC. An understanding of PAC structure-activity relationship is becoming feasible due to advancements, not only in obtaining purified PAC fractions that allow accurate estimation, but also in high-resolution MS methodologies, specifically, MALDI-TOF MS. A recent MALDI-TOF MS deconvolution method allows quantification of the ratios of A-type to B-type bonds enabling characteristic fingerprints. Moreover, the generation of fluorescently labeled PAC allows visualization of the interaction between ExPEC and PAC with microscopy. These tools can be used to establish structure-activity relationships between PAC and UTI and give insight on the mechanism of action of these compounds in the gut without being absorbed." @default.
- W2028294842 created "2016-06-24" @default.
- W2028294842 creator A5000067957 @default.
- W2028294842 creator A5087794950 @default.
- W2028294842 creator A5088131752 @default.
- W2028294842 date "2015-06-01" @default.
- W2028294842 modified "2023-10-08" @default.
- W2028294842 title "Methods to determine effects of cranberry proanthocyanidins on extraintestinal infections: Relevance for urinary tract health" @default.
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