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- W2028294966 abstract "Coenzyme Q or ubiquinone (CoQ) plays several functional roles in cellular processes, among which the most well-recognized is the translocation of protons across the inner mitochondrial membrane and the transfer of electrons from oxidoreductases, such as NADH-Q-, succinate-Q-, α-glycerophosphate-Q-, and dihydroorotate-Q-oxidoreductase, to Q-cytochrome c oxidoreductase in the mitochondrial electron transport chain. CoQ and vitamin E or α- tocopheral are lipoidal substances, present within the hydrophobic domain of the phospholipid bilayer of cellular membranes. CoQ exists in three alternate redox states—namely, fully oxidized or ubiquinone (Q); partially reduced, ubisemiquinone (·QH), which is a free radical; and fully reduced or ubiquinol (QH2). In vivo interaction between CoQ and α- tocopherol is indicated by the increase in α-tocopherol content of mitochondria in response to CoQ intake; however, α-tocopherol intake has no effect on CoQ content. Mitochondrial augmentation with α-tocopherol in vivo and in vitro results in a decrease in the rate of O2·-generation by submitochondrial particles (SMPs). This relationship may be because of a “sparing/regeneration” effect of CoQ on α-tocopherol that is supported by (1) in vitro studies showing that CoQ can react with tocopheroxyl radicals to regenerate α-tocopherol, (2) the fact that loss of α-tocopherol in the mitochondrial membranes is progressively stemmed by elevation of the molar ratio of CoQ to α-tocopherol, (3) the fact that the reactivity of ubiquinol with peroxyl radicals is much lower than that of α-tocopherol, and (4) the fact that elevation in CoQ level in mitochondria by dietary supplementation is linked to a corresponding rise in α-tocopherol content." @default.
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- W2028294966 date "1990-01-01" @default.
- W2028294966 modified "2023-10-14" @default.
- W2028294966 title "MPTP and brain oxidative stress" @default.
- W2028294966 doi "https://doi.org/10.1016/0891-5849(90)90267-m" @default.
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