FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028296890> ?p ?o ?g. }

• W2028296890 endingPage "258" @default.
• W2028296890 startingPage "249" @default.
• W2028296890 abstract "The current investigation examines the changes in the expression of pepsinogen C and cathepsin D and E genes in the gastric mucosa during aging and following physiological stimuli of fasting and refeeding. Northern blot analysis of gastric mucosal RNA, isolated from overnight fasted 6-, 12-, and 24-month-old male Fischer 344 rats, revealed that although steady-state mRNA levels of each of these proteases remained essentially unchanged between 6 and 12 months of age, in 24-month-old rats the levels were decreased by about 60%, when compared with their younger counterparts. Interestingly, the relative concentration of ß-actin mRNA—but not 18s rRNA—in 12- and 24-month-old rats was also decreased by 23% and 37%, respectively, when compared with 6-month-old animals. In the next set of experiments, groups of young (3 month) and aged (24 month) rats were either fed throughout (controls) or fasted for 48 h and then fed for 6 h and 24 h. Gastric mucosal RNA from each group was assayed for steady-state mRNA levels of pepsinogen C and cathepsin D. Results showed that, whereas in young rats fasting decreased pepsinogen C and cathepsin D mRNAs by 80–85%, in aged rats only pepsinogen mRNA was significantly decreased (45%), when compared with the corresponding initial fed controls. In both age groups, refeeding increased pepsinogen C mRNA concentration essentially to the respective initial fed levels. In contrast, cathepsin D mRNA levels in the gastric mucosa of aged rats was affected neither by fasting nor by refeeding. Our current data show that aging not only diminishes the expression of protease genes in the gastric mucosa, but also the expression of one of its structural genes, ß-actin. In addition, responsiveness of these protease genes to the physiological stimuli of fasting and refeeding is also attenuated by aging. We postulate that these age-related changes may in part be due to diminished differentiation of gastric mucosal cells." @default.
• W2028296890 created "2016-06-24" @default.
• W2028296890 creator A5017264581 @default.
• W2028296890 creator A5029214095 @default.
• W2028296890 creator A5044873724 @default.
• W2028296890 date "1993-06-01" @default.
• W2028296890 modified "2023-10-16" @default.
• W2028296890 title "Expression of protease genes in the gastric mucosa during aging" @default.
• W2028296890 cites W1495180194 @default.
• W2028296890 cites W1969975247 @default.
• W2028296890 cites W1970002558 @default.
• W2028296890 cites W1970821962 @default.
• W2028296890 cites W2007857125 @default.
• W2028296890 cites W2010116952 @default.
• W2028296890 cites W2020628888 @default.
• W2028296890 cites W2045497939 @default.
• W2028296890 cites W2074784791 @default.
• W2028296890 cites W2075849672 @default.
• W2028296890 cites W2076711593 @default.
• W2028296890 cites W2085847163 @default.
• W2028296890 cites W2088986997 @default.
• W2028296890 cites W2092910621 @default.
• W2028296890 cites W2103174300 @default.
• W2028296890 cites W2117897299 @default.
• W2028296890 cites W2150073376 @default.
• W2028296890 cites W2196033874 @default.
• W2028296890 cites W2237696491 @default.
• W2028296890 cites W2287457966 @default.
• W2028296890 cites W2316638406 @default.
• W2028296890 cites W2409018741 @default.
• W2028296890 cites W2468190596 @default.
• W2028296890 cites W2468976528 @default.
• W2028296890 cites W2474952801 @default.
• W2028296890 cites W2588742553 @default.
• W2028296890 doi "https://doi.org/10.1016/0531-5565(93)90032-9" @default.
• W2028296890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8344396" @default.
• W2028296890 hasPublicationYear "1993" @default.
• W2028296890 type Work @default.
• W2028296890 sameAs 2028296890 @default.
• W2028296890 citedByCount "25" @default.
• W2028296890 countsByYear W20282968902014 @default.
• W2028296890 countsByYear W20282968902017 @default.
• W2028296890 countsByYear W20282968902020 @default.
• W2028296890 countsByYear W20282968902021 @default.
• W2028296890 countsByYear W20282968902022 @default.
• W2028296890 crossrefType "journal-article" @default.
• W2028296890 hasAuthorship W2028296890A5017264581 @default.
• W2028296890 hasAuthorship W2028296890A5029214095 @default.
• W2028296890 hasAuthorship W2028296890A5044873724 @default.
• W2028296890 hasConcept C104317684 @default.
• W2028296890 hasConcept C105580179 @default.
• W2028296890 hasConcept C126322002 @default.
• W2028296890 hasConcept C134018914 @default.
• W2028296890 hasConcept C150194340 @default.
• W2028296890 hasConcept C16311235 @default.
• W2028296890 hasConcept C167844969 @default.
• W2028296890 hasConcept C173633252 @default.
• W2028296890 hasConcept C181199279 @default.
• W2028296890 hasConcept C182220744 @default.
• W2028296890 hasConcept C2779422922 @default.
• W2028296890 hasConcept C2780034444 @default.
• W2028296890 hasConcept C2781443798 @default.
• W2028296890 hasConcept C28021979 @default.
• W2028296890 hasConcept C55493867 @default.
• W2028296890 hasConcept C71924100 @default.
• W2028296890 hasConcept C86803240 @default.
• W2028296890 hasConceptScore W2028296890C104317684 @default.
• W2028296890 hasConceptScore W2028296890C105580179 @default.
• W2028296890 hasConceptScore W2028296890C126322002 @default.
• W2028296890 hasConceptScore W2028296890C134018914 @default.
• W2028296890 hasConceptScore W2028296890C150194340 @default.
• W2028296890 hasConceptScore W2028296890C16311235 @default.
• W2028296890 hasConceptScore W2028296890C167844969 @default.
• W2028296890 hasConceptScore W2028296890C173633252 @default.
• W2028296890 hasConceptScore W2028296890C181199279 @default.
• W2028296890 hasConceptScore W2028296890C182220744 @default.
• W2028296890 hasConceptScore W2028296890C2779422922 @default.
• W2028296890 hasConceptScore W2028296890C2780034444 @default.
• W2028296890 hasConceptScore W2028296890C2781443798 @default.
• W2028296890 hasConceptScore W2028296890C28021979 @default.
• W2028296890 hasConceptScore W2028296890C55493867 @default.
• W2028296890 hasConceptScore W2028296890C71924100 @default.
• W2028296890 hasConceptScore W2028296890C86803240 @default.
• W2028296890 hasIssue "3" @default.
• W2028296890 hasLocation W20282968901 @default.
• W2028296890 hasLocation W20282968902 @default.
• W2028296890 hasOpenAccess W2028296890 @default.
• W2028296890 hasPrimaryLocation W20282968901 @default.
• W2028296890 hasRelatedWork W1985314670 @default.
• W2028296890 hasRelatedWork W1988760146 @default.
• W2028296890 hasRelatedWork W2028296890 @default.
• W2028296890 hasRelatedWork W2034141562 @default.
• W2028296890 hasRelatedWork W2084775173 @default.
• W2028296890 hasRelatedWork W2133862918 @default.
• W2028296890 hasRelatedWork W2156001803 @default.
• W2028296890 hasRelatedWork W2463685355 @default.
• W2028296890 hasRelatedWork W3113657949 @default.
• W2028296890 hasRelatedWork W4253545523 @default.

• next