Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028297893> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2028297893 endingPage "23" @default.
- W2028297893 startingPage "21" @default.
- W2028297893 abstract "Gastric acid is believed to be an important etiological factor in the pathogenesis of Barrett's esophagus. Pulsatile acid exposure increases cell proliferation in ex vivo Barrrett's tissue and normalization of esophageal pH reverses this. Proton pump inhibitors (PPIs) are the mainstay of therapy in Barrett's esophagus, and have numerous beneficial effects including symptom control, reduction of inflammation, and promotion of the development of squamous islands. However, PPI therapy causes hypergastrinemia and has not prevented recent increase in the incidences of esophageal cancer. Additionally, evidence presented here by Feagins et al. suggests that acid exposure has a p53-mediated, antiproliferative effect on a nondysplastic Barrett's epithelial cell line, an effect that acid suppression might abrogate. These complex pH, inflammation, and growth factor biological interactions can be most reliably tested in large clinical trials with hard end points like cancer conversion or all causes of mortality. Combining the anti-inflammatory effects of acid suppression with aspirin, a nonsteroidal anti-inflammatory agent, is the subject of the AspECT clinical trial, and this may be the future of chemoprevention in Barrett's." @default.
- W2028297893 created "2016-06-24" @default.
- W2028297893 creator A5034762894 @default.
- W2028297893 creator A5081837421 @default.
- W2028297893 date "2007-01-01" @default.
- W2028297893 modified "2023-09-23" @default.
- W2028297893 title "The Evidence Base of Proton Pump Inhibitor Chemopreventative Agents in Barrett's Esophagus—The Good, The Bad, and The Flawed!" @default.
- W2028297893 cites W1598952686 @default.
- W2028297893 cites W1964010321 @default.
- W2028297893 cites W1966130491 @default.
- W2028297893 cites W1972781271 @default.
- W2028297893 cites W1987709845 @default.
- W2028297893 cites W1988220078 @default.
- W2028297893 cites W2005384353 @default.
- W2028297893 cites W2008180069 @default.
- W2028297893 cites W2028277951 @default.
- W2028297893 cites W2035163301 @default.
- W2028297893 cites W2043707891 @default.
- W2028297893 cites W2046451894 @default.
- W2028297893 cites W2056484082 @default.
- W2028297893 cites W2067273677 @default.
- W2028297893 cites W2090909349 @default.
- W2028297893 cites W2097997344 @default.
- W2028297893 cites W2106901795 @default.
- W2028297893 cites W2125968258 @default.
- W2028297893 cites W2128510972 @default.
- W2028297893 cites W2139853624 @default.
- W2028297893 cites W2151869041 @default.
- W2028297893 cites W2156571438 @default.
- W2028297893 cites W2166807818 @default.
- W2028297893 cites W2170202550 @default.
- W2028297893 cites W2314540303 @default.
- W2028297893 cites W2322813430 @default.
- W2028297893 doi "https://doi.org/10.1111/j.1572-0241.2006.01033.x" @default.
- W2028297893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17266685" @default.
- W2028297893 hasPublicationYear "2007" @default.
- W2028297893 type Work @default.
- W2028297893 sameAs 2028297893 @default.
- W2028297893 citedByCount "30" @default.
- W2028297893 countsByYear W20282978932012 @default.
- W2028297893 countsByYear W20282978932013 @default.
- W2028297893 countsByYear W20282978932016 @default.
- W2028297893 countsByYear W20282978932018 @default.
- W2028297893 countsByYear W20282978932021 @default.
- W2028297893 countsByYear W20282978932022 @default.
- W2028297893 countsByYear W20282978932023 @default.
- W2028297893 crossrefType "journal-article" @default.
- W2028297893 hasAuthorship W2028297893A5034762894 @default.
- W2028297893 hasAuthorship W2028297893A5081837421 @default.
- W2028297893 hasConcept C121608353 @default.
- W2028297893 hasConcept C126322002 @default.
- W2028297893 hasConcept C2776914184 @default.
- W2028297893 hasConcept C2777628954 @default.
- W2028297893 hasConcept C2777819096 @default.
- W2028297893 hasConcept C2778589982 @default.
- W2028297893 hasConcept C2779742542 @default.
- W2028297893 hasConcept C2781025758 @default.
- W2028297893 hasConcept C2781182431 @default.
- W2028297893 hasConcept C535046627 @default.
- W2028297893 hasConcept C71924100 @default.
- W2028297893 hasConcept C90924648 @default.
- W2028297893 hasConceptScore W2028297893C121608353 @default.
- W2028297893 hasConceptScore W2028297893C126322002 @default.
- W2028297893 hasConceptScore W2028297893C2776914184 @default.
- W2028297893 hasConceptScore W2028297893C2777628954 @default.
- W2028297893 hasConceptScore W2028297893C2777819096 @default.
- W2028297893 hasConceptScore W2028297893C2778589982 @default.
- W2028297893 hasConceptScore W2028297893C2779742542 @default.
- W2028297893 hasConceptScore W2028297893C2781025758 @default.
- W2028297893 hasConceptScore W2028297893C2781182431 @default.
- W2028297893 hasConceptScore W2028297893C535046627 @default.
- W2028297893 hasConceptScore W2028297893C71924100 @default.
- W2028297893 hasConceptScore W2028297893C90924648 @default.
- W2028297893 hasIssue "1" @default.
- W2028297893 hasLocation W20282978931 @default.
- W2028297893 hasLocation W20282978932 @default.
- W2028297893 hasOpenAccess W2028297893 @default.
- W2028297893 hasPrimaryLocation W20282978931 @default.
- W2028297893 hasRelatedWork W115503447 @default.
- W2028297893 hasRelatedWork W2007120802 @default.
- W2028297893 hasRelatedWork W2011957760 @default.
- W2028297893 hasRelatedWork W2021004426 @default.
- W2028297893 hasRelatedWork W2136839211 @default.
- W2028297893 hasRelatedWork W2188539336 @default.
- W2028297893 hasRelatedWork W2333129556 @default.
- W2028297893 hasRelatedWork W2333813441 @default.
- W2028297893 hasRelatedWork W2411319260 @default.
- W2028297893 hasRelatedWork W2500249488 @default.
- W2028297893 hasVolume "102" @default.
- W2028297893 isParatext "false" @default.
- W2028297893 isRetracted "false" @default.
- W2028297893 magId "2028297893" @default.
- W2028297893 workType "article" @default.