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- W2028298077 abstract "Abstract Background The gene daf-2 encodes the single insulin/insulin growth factor-1-like receptor of Caenorhabditis elegans . The reduction-of-function allele e1370 induces several metabolic alterations and doubles lifespan. Results We found that the e1370 mutation alters aerobic energy production substantially. In wild-type worms the abundance of key mitochondrial proteins declines with age, accompanied by a dramatic decrease in energy production, although the mitochondrial mass, inferred from the mitochondrial DNA copy number, remains unaltered. In contrast, the age-dependent decrease of both key mitochondrial proteins and bioenergetic competence is considerably attenuated in daf-2(e1370) adult animals. The increase in daf-2(e1370) mitochondrial competence is associated with a higher membrane potential and increased reactive oxygen species production, but with little damage to mitochondrial protein or DNA. Together these results point to a higher energetic efficiency of daf-2(e1370) animals. Conclusions We conclude that low daf-2 function alters the overall rate of ageing by a yet unidentified mechanism with an indirect protective effect on mitochondrial function." @default.
- W2028298077 created "2016-06-24" @default.
- W2028298077 creator A5003807798 @default.
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- W2028298077 date "2010-06-28" @default.
- W2028298077 modified "2023-09-25" @default.
- W2028298077 title "Disruption of insulin signalling preserves bioenergetic competence of mitochondria in ageing Caenorhabditis elegans" @default.
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- W2028298077 doi "https://doi.org/10.1186/1741-7007-8-91" @default.
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