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• W2028305058 endingPage "57" @default.
• W2028305058 startingPage "47" @default.
• W2028305058 abstract "Except for their extra- and intra-cellular interfaces, cell membranes are hydrophobic and inhibit the transport of hydrophilic molecules. Metalloids in aqueous solutions form chemical species with oxygen and hydroxyl groups and, therefore, exist as hydrophilic neutral polar solutes or as hydrophilic anions. This characteristic of metalloids introduces a large barrier for their passage through the cell membrane via unaided diffusion. The necessity for an uptake mechanism for metalloids arises from the requirement of these species for the maintenance of life, such as the need of boron for plant cells. Conversely, the transport of these species out of the cell is necessary because some metalloids are toxic, such as arsenic and antimony, and their entrance into the cell is undesirable. The undesired uptake of these toxic species is possible via pathways designed for the uptake of other structurally and chemically similar essential compounds. Therefore, the extrusion of arsenic and antimony out of the cell is an example of a detoxification mechanism. As a consequence of the hydrophobic character of the cell membrane in all living systems, the main route for the uptake and efflux of metalloids is facilitated by transmembrane proteins, driven either by concentration gradients or by energy-fueled pumps. However, metalloids forming or embedded in nano-sized particles escape the need to cross the cell membrane because these particles can be taken into the cell by endocytosis. Here, we review the uptake and efflux pathways of boron, silicon, arsenic, and antimony through the cell membranes of different organisms and the protein channels involved in these processes. In particular, passive diffusion via aquaglyceroporins, active transport via primary and secondary ion pumps, extrusion into vacuoles of metalloid-thiol conjugates via ATP-binding cassette, the efflux of methylated metalloids, and endocytosis are summarized." @default.
• W2028305058 created "2016-06-24" @default.
• W2028305058 creator A5016053493 @default.
• W2028305058 creator A5047522640 @default.
• W2028305058 date "2012-04-01" @default.
• W2028305058 modified "2023-10-06" @default.
• W2028305058 title "Transport routes of metalloids into and out of the cell: A review of the current knowledge" @default.
• W2028305058 cites W108623912 @default.
• W2028305058 cites W1492501257 @default.
• W2028305058 cites W1533645179 @default.
• W2028305058 cites W1540963998 @default.
• W2028305058 cites W1553759963 @default.
• W2028305058 cites W1591572368 @default.
• W2028305058 cites W1597184000 @default.
• W2028305058 cites W1617637522 @default.
• W2028305058 cites W1645325987 @default.
• W2028305058 cites W1655884958 @default.
• W2028305058 cites W1667273974 @default.
• W2028305058 cites W1923149556 @default.
• W2028305058 cites W1925784940 @default.
• W2028305058 cites W1931176121 @default.
• W2028305058 cites W1947778485 @default.
• W2028305058 cites W1968997803 @default.
• W2028305058 cites W1971206002 @default.
• W2028305058 cites W1973341903 @default.
• W2028305058 cites W1980290112 @default.
• W2028305058 cites W1981697985 @default.
• W2028305058 cites W1982330330 @default.
• W2028305058 cites W1983722360 @default.
• W2028305058 cites W1984105235 @default.
• W2028305058 cites W1984423376 @default.
• W2028305058 cites W1985309426 @default.
• W2028305058 cites W1986866255 @default.
• W2028305058 cites W1987638194 @default.
• W2028305058 cites W1987995270 @default.
• W2028305058 cites W1989511088 @default.
• W2028305058 cites W1990923889 @default.
• W2028305058 cites W1991529393 @default.
• W2028305058 cites W1992192666 @default.
• W2028305058 cites W1992215123 @default.
• W2028305058 cites W1993390114 @default.
• W2028305058 cites W1994218586 @default.
• W2028305058 cites W1995997560 @default.
• W2028305058 cites W1999165043 @default.
• W2028305058 cites W2000755933 @default.
• W2028305058 cites W2001396364 @default.
• W2028305058 cites W2003197024 @default.
• W2028305058 cites W2005546760 @default.
• W2028305058 cites W2008507062 @default.
• W2028305058 cites W2009094231 @default.
• W2028305058 cites W2009230458 @default.
• W2028305058 cites W2012841076 @default.
• W2028305058 cites W2013112981 @default.
• W2028305058 cites W2016600100 @default.
• W2028305058 cites W2021645288 @default.
• W2028305058 cites W2023312630 @default.
• W2028305058 cites W2024174792 @default.
• W2028305058 cites W2029627379 @default.
• W2028305058 cites W2031495010 @default.
• W2028305058 cites W2031775282 @default.
• W2028305058 cites W2032540579 @default.
• W2028305058 cites W2032709546 @default.
• W2028305058 cites W2033441569 @default.
• W2028305058 cites W2034998098 @default.
• W2028305058 cites W2036319458 @default.
• W2028305058 cites W2036471969 @default.
• W2028305058 cites W2038428699 @default.
• W2028305058 cites W2040211932 @default.
• W2028305058 cites W2040297713 @default.
• W2028305058 cites W2041105700 @default.
• W2028305058 cites W2041711159 @default.
• W2028305058 cites W2043453969 @default.
• W2028305058 cites W2044095192 @default.
• W2028305058 cites W2046444528 @default.
• W2028305058 cites W2048887028 @default.
• W2028305058 cites W2058849119 @default.
• W2028305058 cites W2059774444 @default.
• W2028305058 cites W2060200508 @default.
• W2028305058 cites W2063733074 @default.
• W2028305058 cites W2067236876 @default.
• W2028305058 cites W2067332665 @default.
• W2028305058 cites W2067584349 @default.
• W2028305058 cites W2068934404 @default.
• W2028305058 cites W2070262867 @default.
• W2028305058 cites W2073985048 @default.
• W2028305058 cites W2074644527 @default.
• W2028305058 cites W2076080696 @default.
• W2028305058 cites W2079980536 @default.
• W2028305058 cites W2080245111 @default.
• W2028305058 cites W2080747540 @default.
• W2028305058 cites W2083225699 @default.
• W2028305058 cites W2084070944 @default.
• W2028305058 cites W2086933987 @default.
• W2028305058 cites W2088355691 @default.
• W2028305058 cites W2091297151 @default.
• W2028305058 cites W2092398899 @default.
• W2028305058 cites W2093571257 @default.
• W2028305058 cites W2095093199 @default.

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