Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028305453> ?p ?o ?g. }
- W2028305453 endingPage "446" @default.
- W2028305453 startingPage "439" @default.
- W2028305453 abstract "Integrin activation is essential for dynamically linking the extracellular environment and cytoskeletal/signaling networks. Activation is controlled by integrins' short cytoplasmic tails (CTs). It is widely accepted that the head domain of talin (talin-H) can mediate integrin activation by binding to two sites in integrin β's CT; in integrin β3 this is an NPLY747 motif and the membrane-proximal region. Here, we show that the C-terminal region of integrin β3 CT, composed of a conserved TS752T region and NITY759 motif, supports integrin activation by binding to a cytosolic binding partner, kindlin-2, a widely distributed PTB domain protein. Co-transfection of kindlin-2 with talin-H results in a synergistic enhancement of integrin αIIbβ3 activation. Furthermore, siRNA knockdown of endogenous kindlin-2 impairs talin-induced αIIbβ3 activation in transfected CHO cells and blunts αvβ3-mediated adhesion and migration of endothelial cells. Our results thus identify kindlin-2 as a novel regulator of integrin activation; it functions as a coactivator." @default.
- W2028305453 created "2016-06-24" @default.
- W2028305453 creator A5018355628 @default.
- W2028305453 creator A5022614068 @default.
- W2028305453 creator A5042974889 @default.
- W2028305453 creator A5088556973 @default.
- W2028305453 date "2008-05-05" @default.
- W2028305453 modified "2023-10-02" @default.
- W2028305453 title "Kindlin-2 (Mig-2): a co-activator of β3 integrins" @default.
- W2028305453 cites W1500795239 @default.
- W2028305453 cites W1543980776 @default.
- W2028305453 cites W1576773659 @default.
- W2028305453 cites W1651672993 @default.
- W2028305453 cites W1970483666 @default.
- W2028305453 cites W1981181636 @default.
- W2028305453 cites W1982617894 @default.
- W2028305453 cites W1985169370 @default.
- W2028305453 cites W1993312924 @default.
- W2028305453 cites W2002219680 @default.
- W2028305453 cites W2002590458 @default.
- W2028305453 cites W2016129682 @default.
- W2028305453 cites W2023693583 @default.
- W2028305453 cites W2031003711 @default.
- W2028305453 cites W2031261181 @default.
- W2028305453 cites W2039453220 @default.
- W2028305453 cites W2039838953 @default.
- W2028305453 cites W2040379229 @default.
- W2028305453 cites W2040948261 @default.
- W2028305453 cites W2050476475 @default.
- W2028305453 cites W2054660342 @default.
- W2028305453 cites W2055614158 @default.
- W2028305453 cites W2101346022 @default.
- W2028305453 cites W2118357046 @default.
- W2028305453 cites W2131309206 @default.
- W2028305453 cites W2138223004 @default.
- W2028305453 cites W2157012084 @default.
- W2028305453 cites W2169811294 @default.
- W2028305453 cites W3110913815 @default.
- W2028305453 doi "https://doi.org/10.1083/jcb.200710196" @default.
- W2028305453 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2364684" @default.
- W2028305453 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18458155" @default.
- W2028305453 hasPublicationYear "2008" @default.
- W2028305453 type Work @default.
- W2028305453 sameAs 2028305453 @default.
- W2028305453 citedByCount "328" @default.
- W2028305453 countsByYear W20283054532012 @default.
- W2028305453 countsByYear W20283054532013 @default.
- W2028305453 countsByYear W20283054532014 @default.
- W2028305453 countsByYear W20283054532015 @default.
- W2028305453 countsByYear W20283054532016 @default.
- W2028305453 countsByYear W20283054532017 @default.
- W2028305453 countsByYear W20283054532018 @default.
- W2028305453 countsByYear W20283054532019 @default.
- W2028305453 countsByYear W20283054532020 @default.
- W2028305453 countsByYear W20283054532021 @default.
- W2028305453 countsByYear W20283054532022 @default.
- W2028305453 countsByYear W20283054532023 @default.
- W2028305453 crossrefType "journal-article" @default.
- W2028305453 hasAuthorship W2028305453A5018355628 @default.
- W2028305453 hasAuthorship W2028305453A5022614068 @default.
- W2028305453 hasAuthorship W2028305453A5042974889 @default.
- W2028305453 hasAuthorship W2028305453A5088556973 @default.
- W2028305453 hasBestOaLocation W20283054531 @default.
- W2028305453 hasConcept C104317684 @default.
- W2028305453 hasConcept C119524353 @default.
- W2028305453 hasConcept C1491633281 @default.
- W2028305453 hasConcept C156585808 @default.
- W2028305453 hasConcept C170493617 @default.
- W2028305453 hasConcept C171779818 @default.
- W2028305453 hasConcept C173396325 @default.
- W2028305453 hasConcept C195687474 @default.
- W2028305453 hasConcept C2779358239 @default.
- W2028305453 hasConcept C4894155 @default.
- W2028305453 hasConcept C54009773 @default.
- W2028305453 hasConcept C55493867 @default.
- W2028305453 hasConcept C85789140 @default.
- W2028305453 hasConcept C86803240 @default.
- W2028305453 hasConcept C88045685 @default.
- W2028305453 hasConcept C95444343 @default.
- W2028305453 hasConceptScore W2028305453C104317684 @default.
- W2028305453 hasConceptScore W2028305453C119524353 @default.
- W2028305453 hasConceptScore W2028305453C1491633281 @default.
- W2028305453 hasConceptScore W2028305453C156585808 @default.
- W2028305453 hasConceptScore W2028305453C170493617 @default.
- W2028305453 hasConceptScore W2028305453C171779818 @default.
- W2028305453 hasConceptScore W2028305453C173396325 @default.
- W2028305453 hasConceptScore W2028305453C195687474 @default.
- W2028305453 hasConceptScore W2028305453C2779358239 @default.
- W2028305453 hasConceptScore W2028305453C4894155 @default.
- W2028305453 hasConceptScore W2028305453C54009773 @default.
- W2028305453 hasConceptScore W2028305453C55493867 @default.
- W2028305453 hasConceptScore W2028305453C85789140 @default.
- W2028305453 hasConceptScore W2028305453C86803240 @default.
- W2028305453 hasConceptScore W2028305453C88045685 @default.
- W2028305453 hasConceptScore W2028305453C95444343 @default.
- W2028305453 hasIssue "3" @default.
- W2028305453 hasLocation W20283054531 @default.
- W2028305453 hasLocation W20283054532 @default.