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- W2028305651 abstract "Purpose: To design, develop and test a novel system for rapidly acquiring large amounts of in-vitro RBE data for protons as a function of LET, dose per fraction, dose rate, end point, and oxygenation for a wide range of cell lines. Methods: Using the Geant4 Monte Carlo toolkit, we designed a specialized range compensator to simultaneously expose cells plated in 96 wells (12 columns by 8 rows) to different doses and variable LETs from selected portions of pristine proton beams from the entrance to points just beyond the Bragg peak. The use of 96-well plates can facilitate future high-throughput and high-resolution measurements. To minimize the spread of LET, we utilized monoenergetic uniformly scanned proton beams. Using a sequence of entrance doses and variable LETs, an RBE matrix related to different pairs of doses and LETs can be acquired in a relatively small number of exposures. In this study, we utilized the standard clonogenic assay for lung-cancer cell lines grown in 96-well plates. The compensator is mounted in the scanning beam snout with the beam directed toward the ceiling. In each exposure, one 96-well plate was positioned downstream for irradiation. Results: Experimental data for lung cancer cells exposed to 79.7 MeV protons showed a significant increase in cell kill as a function of LET at locations close to the distal edge of the Bragg peak. For LET values of 8.34, 11.6, 13.5 and 14.6 keV/μm, the surviving fractions were found to be 0.24, 0.18, 0.088 and 0.031 at 4 Gy and 0.11, 0.074, 0.024 and 0.0035 at 6 Gy. Conclusion: The experimental design developed is a viable approach to rapidly acquire large amounts of accurate in-vitro RBE data. We plan to further improve the design to achieve higher accuracy and throughput, thereby facilitating the irradiation of multiple cell types. NCI grant P01CA021239" @default.
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- W2028305651 date "2013-06-01" @default.
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- W2028305651 title "TH-F-105-03: Experimental Design and Preliminary Results for High-Resolution and High-Throughput In-Vitro Measurements of Proton RBE" @default.
- W2028305651 doi "https://doi.org/10.1118/1.4815816" @default.
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