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- W2028305959 abstract "Retroviral vectors from both oncoretroviral and lentiviral origins have a great potential as gene delivery vehicles. A number of research groups have devoted considerable effort to the development of large-scale production strategies for retroviral vectors. However, the manufacturing of clinical-grade vectors for gene therapy, especially for in vivo applications, additionally requires scaleable purification strategies to remove the contaminants present in the harvested supernatants while preserving the functionality of the vectors. In this article, we review recent advances made in the field of downstream processing of retroviral vectors. The methods currently described in the literature for clarification, concentration and purification of retroviral vectors will be presented, with special emphasis on novel chromatography methods that open up the possibility to selectively and efficiently purify retroviruses on a large-scale. Problems associated with stability and quantification of retroviral particles will be outlined and future challenges will be discussed." @default.
- W2028305959 created "2016-06-24" @default.
- W2028305959 creator A5066440155 @default.
- W2028305959 creator A5069297606 @default.
- W2028305959 creator A5079295525 @default.
- W2028305959 date "2006-05-01" @default.
- W2028305959 modified "2023-09-23" @default.
- W2028305959 title "Downstream processing of oncoretroviral and lentiviral gene therapy vectors" @default.
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- W2028305959 doi "https://doi.org/10.1016/j.biotechadv.2005.12.001" @default.
- W2028305959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16448798" @default.
- W2028305959 hasPublicationYear "2006" @default.