Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028306511> ?p ?o ?g. }
- W2028306511 endingPage "1546" @default.
- W2028306511 startingPage "1540" @default.
- W2028306511 abstract "LPS signaling is mediated through MyD88-dependent and -independent pathways, activating NF-κB, MAP kinases and IRF3. Cot/Tpl2 is an essential upstream kinase in LPS-mediated activation of ERKs. Here we explore the roles of MyD88 and Cot/Tpl2 in LPS-induced chemokine expression by studying myd88 −/− and cot/tpl2 −/− macrophages. Among the nine LPS-responsive chemokines examined, mRNA induction of ccl5, cxcl10, and cxcl13 is mediated through the MyD88-independent pathway. Notably, Cot/Tpl2-ERK signaling axis exerts negative effects on the expression of these three chemokines. In contrast, LPS-induced gene expression of ccl2, ccl7, cxcl2, cxcl3, ccl8, and cxcl9 is mediated in the MyD88-dependent manner. The Cot/Tpl2-ERK axis promotes the expression of the first four and inhibits the expression of the latter two. Thus, LPS induces expression of multiple chemokines through various signaling pathways in macrophages." @default.
- W2028306511 created "2016-06-24" @default.
- W2028306511 creator A5000577384 @default.
- W2028306511 creator A5053249745 @default.
- W2028306511 creator A5061158540 @default.
- W2028306511 creator A5066542297 @default.
- W2028306511 creator A5077515022 @default.
- W2028306511 date "2012-04-21" @default.
- W2028306511 modified "2023-10-16" @default.
- W2028306511 title "LPS-induced chemokine expression in both MyD88-dependent and -independent manners is regulated by Cot/Tpl2-ERK axis in macrophages" @default.
- W2028306511 cites W1488327245 @default.
- W2028306511 cites W1501690710 @default.
- W2028306511 cites W1524786677 @default.
- W2028306511 cites W1586373415 @default.
- W2028306511 cites W1596483042 @default.
- W2028306511 cites W1598572197 @default.
- W2028306511 cites W1625203433 @default.
- W2028306511 cites W1966772446 @default.
- W2028306511 cites W1967739997 @default.
- W2028306511 cites W1982270701 @default.
- W2028306511 cites W1992415952 @default.
- W2028306511 cites W1996548703 @default.
- W2028306511 cites W2001192666 @default.
- W2028306511 cites W2001668931 @default.
- W2028306511 cites W2002066494 @default.
- W2028306511 cites W2013601771 @default.
- W2028306511 cites W2026553431 @default.
- W2028306511 cites W2049197565 @default.
- W2028306511 cites W2055182237 @default.
- W2028306511 cites W2060222319 @default.
- W2028306511 cites W2065833103 @default.
- W2028306511 cites W2072564827 @default.
- W2028306511 cites W2075799527 @default.
- W2028306511 cites W2077300798 @default.
- W2028306511 cites W2077537034 @default.
- W2028306511 cites W2079181497 @default.
- W2028306511 cites W2081462803 @default.
- W2028306511 cites W2082890018 @default.
- W2028306511 cites W2082942944 @default.
- W2028306511 cites W2086713654 @default.
- W2028306511 cites W2095833996 @default.
- W2028306511 cites W2102849896 @default.
- W2028306511 cites W2104907470 @default.
- W2028306511 cites W2105901060 @default.
- W2028306511 cites W2109491705 @default.
- W2028306511 cites W2111428445 @default.
- W2028306511 cites W2112042684 @default.
- W2028306511 cites W2113668856 @default.
- W2028306511 cites W2114123652 @default.
- W2028306511 cites W2121284065 @default.
- W2028306511 cites W2148387062 @default.
- W2028306511 cites W2171260427 @default.
- W2028306511 cites W4211264883 @default.
- W2028306511 cites W4296792904 @default.
- W2028306511 doi "https://doi.org/10.1016/j.febslet.2012.04.018" @default.
- W2028306511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22673523" @default.
- W2028306511 hasPublicationYear "2012" @default.
- W2028306511 type Work @default.
- W2028306511 sameAs 2028306511 @default.
- W2028306511 citedByCount "75" @default.
- W2028306511 countsByYear W20283065112012 @default.
- W2028306511 countsByYear W20283065112013 @default.
- W2028306511 countsByYear W20283065112014 @default.
- W2028306511 countsByYear W20283065112015 @default.
- W2028306511 countsByYear W20283065112016 @default.
- W2028306511 countsByYear W20283065112017 @default.
- W2028306511 countsByYear W20283065112018 @default.
- W2028306511 countsByYear W20283065112019 @default.
- W2028306511 countsByYear W20283065112020 @default.
- W2028306511 countsByYear W20283065112021 @default.
- W2028306511 countsByYear W20283065112022 @default.
- W2028306511 countsByYear W20283065112023 @default.
- W2028306511 crossrefType "journal-article" @default.
- W2028306511 hasAuthorship W2028306511A5000577384 @default.
- W2028306511 hasAuthorship W2028306511A5053249745 @default.
- W2028306511 hasAuthorship W2028306511A5061158540 @default.
- W2028306511 hasAuthorship W2028306511A5066542297 @default.
- W2028306511 hasAuthorship W2028306511A5077515022 @default.
- W2028306511 hasBestOaLocation W20283065111 @default.
- W2028306511 hasConcept C101666144 @default.
- W2028306511 hasConcept C110015553 @default.
- W2028306511 hasConcept C116484652 @default.
- W2028306511 hasConcept C12823836 @default.
- W2028306511 hasConcept C13164669 @default.
- W2028306511 hasConcept C13373296 @default.
- W2028306511 hasConcept C13425408 @default.
- W2028306511 hasConcept C134678942 @default.
- W2028306511 hasConcept C154317977 @default.
- W2028306511 hasConcept C170493617 @default.
- W2028306511 hasConcept C179661763 @default.
- W2028306511 hasConcept C185592680 @default.
- W2028306511 hasConcept C202751555 @default.
- W2028306511 hasConcept C55493867 @default.
- W2028306511 hasConcept C57074206 @default.
- W2028306511 hasConcept C5858377 @default.
- W2028306511 hasConcept C62478195 @default.
- W2028306511 hasConcept C79484868 @default.
- W2028306511 hasConcept C86803240 @default.