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• W2028321111 endingPage "6940" @default.
• W2028321111 startingPage "6936" @default.
• W2028321111 abstract "Protective/suppressive major histocompatibility complex (MHC) class II alleles have been identified in humans and mice where they exert a disease-protective and immunosuppressive effect. Various modes of action have been proposed, among them differential expression of MHC class II genes in different types of antigen-presenting cells impacting on the T helper type 1 (Th1)–Th2 balance. To test this possibility, the expression of H-2 molecules from the four haplotypes H-2 b , H-2 d , H-2 k , and H-2 q was determined on bone marrow-derived macrophages (BMDMs) and splenic B cells. The I-A b and I-E k molecules, both well characterized as protective/suppressive, are expressed at a high level on almost all CD11b + BMDMs for 5–8 days, after which expression slowly declines. In contrast, I-A d , I-A k , and I-A q expression is lower, peaks over a shorter period, and declines more rapidly. No differential expression could be detected on B cells. In addition, the differential MHC class II expression found on macrophages skews the cytokine response of T cells as shown by an in vitro restimulation assay with BMDMs as antigen-presenting cells. The results indicate that macrophages of the protective/suppressive haplotypes express MHC class II molecules at a high level and exert Th1 bias, whereas low-level expression favors a Th2 response. We suggest that the extent of expression of the class II gene gates the back signal from T cells and in this way controls the activity of macrophages. This effect mediated by polymorphic nonexon segments of MHC class II genes may play a role in determining disease susceptibility in humans and mice." @default.
• W2028321111 created "2016-06-24" @default.
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• W2028321111 date "1998-06-09" @default.
• W2028321111 modified "2023-10-12" @default.
• W2028321111 title "Differential expression of major histocompatibility complex class II genes on murine macrophages associated with T cell cytokine profile and protective/suppressive effects" @default.
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• W2028321111 doi "https://doi.org/10.1073/pnas.95.12.6936" @default.
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