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- W2028331460 abstract "Staphylococcal α-hemolysin introduced intravenously in increasing doses (1–20 μg/kg body weight), resulted in collapse of the brain bioelectric activity of rabbits. The rapidity of appearance of changes in the EEG record was directly related to the dose of α-hemolysin introduced. Increase of the dose of toxin did not alter the sequence of changes in the EEG record; however, there was an intensification of the dynamics of the EEG and shortening of the survival of rabbits. The character of the observed changes in the EEG records postulated that the mechanism of action of staphylococcal α-hemolysin involved disturbances of the normal repolarization phase in stimulated nerve cell. Centrophenoxine (p-chlorophenoxyacetic acid-dimethylaminoethylesterchlorohydrate) prolonged brain bioelectric activity and survival following α-hemolysin administration. It is postulated that the centrophenoxine exerted a protective effect on the nerve cell surface preventing the membrane damage from staphylococcal α-hemolysin." @default.
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- W2028331460 date "1968-09-01" @default.
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- W2028331460 title "Brain bioelectric activity in staphylococcal α-hemolysin intoxication" @default.
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- W2028331460 doi "https://doi.org/10.1016/0041-008x(68)90087-2" @default.
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