Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028331937> ?p ?o ?g. }
- W2028331937 endingPage "446" @default.
- W2028331937 startingPage "438" @default.
- W2028331937 abstract "To study the effect of disease duration on the clinical, neuropsychological and [18F]-deoxyglucose (FDG) PET findings in patients with mixed type multiple system atrophy (MSA), this study included 16 controls and 37 mixed-type MSA patients with a shorter than a 3-year history of cerebellar or parkinsonian symptoms. We classified the patients into three groups according to the duration of parkinsonian or cerebellar symptoms (Group I = ≤1 year; II = 13–24 months; III = 25–36 months). We performed UPDRS, international cooperative ataxia rating scale (ICARS), and a neuropsychological test battery. We compared the FDG PET findings of each group of patients with controls. Group I patients frequently had memory and frontal executive dysfunction. They showed hypometabolism in the frontal cortex, anterior cerebellar hemisphere and vermis. They had parkinsonian motor deficits, but no basal ganglia hypometabolism. Group II and III patients frequently had multiple domain cognitive impairments, and showed hypometabolism in the frontal and parieto-temporal cortices. Hypometabolism of the bilateral caudate and the left posterolateral putamen was observed in Group II, and whole striatum in Group III. In summary, the cortical hypometabolism begins in the frontal cortex and spreads to the parieto-temporal cortex in MSA. This spreading pattern coincides with the progressive cognitive decline. Early caudate hypometabolism may also contribute to the cognitive impairment. Parkinsonian motor deficits precede putaminal hypometabolism that begins in its posterolateral part. Cerebellar hypometabolism occurs early in the clinical courses and seems to be a relevant metabolic descriptor of cerebellar deficits." @default.
- W2028331937 created "2016-06-24" @default.
- W2028331937 creator A5006977027 @default.
- W2028331937 creator A5018649609 @default.
- W2028331937 creator A5019076928 @default.
- W2028331937 creator A5031017680 @default.
- W2028331937 creator A5034889878 @default.
- W2028331937 creator A5046500154 @default.
- W2028331937 creator A5060012458 @default.
- W2028331937 creator A5087888043 @default.
- W2028331937 date "2008-02-01" @default.
- W2028331937 modified "2023-10-16" @default.
- W2028331937 title "Effects of disease duration on the clinical features and brain glucose metabolism in patients with mixed type multiple system atrophy" @default.
- W2028331937 cites W1951442280 @default.
- W2028331937 cites W1964984307 @default.
- W2028331937 cites W1966887093 @default.
- W2028331937 cites W1970992086 @default.
- W2028331937 cites W1971367076 @default.
- W2028331937 cites W1977031758 @default.
- W2028331937 cites W1977763786 @default.
- W2028331937 cites W1992563151 @default.
- W2028331937 cites W1996271059 @default.
- W2028331937 cites W2001863520 @default.
- W2028331937 cites W2007568212 @default.
- W2028331937 cites W2008755838 @default.
- W2028331937 cites W2013417905 @default.
- W2028331937 cites W2024985274 @default.
- W2028331937 cites W2031170958 @default.
- W2028331937 cites W2032859244 @default.
- W2028331937 cites W2034328797 @default.
- W2028331937 cites W2039784351 @default.
- W2028331937 cites W2043288745 @default.
- W2028331937 cites W2044201140 @default.
- W2028331937 cites W2050639391 @default.
- W2028331937 cites W2053854391 @default.
- W2028331937 cites W2054265484 @default.
- W2028331937 cites W2054368817 @default.
- W2028331937 cites W2055710528 @default.
- W2028331937 cites W2056548374 @default.
- W2028331937 cites W2057654544 @default.
- W2028331937 cites W2062492266 @default.
- W2028331937 cites W2067034802 @default.
- W2028331937 cites W2068989890 @default.
- W2028331937 cites W2071332161 @default.
- W2028331937 cites W2079565803 @default.
- W2028331937 cites W2083915232 @default.
- W2028331937 cites W2084735903 @default.
- W2028331937 cites W2085693585 @default.
- W2028331937 cites W2086726489 @default.
- W2028331937 cites W2087919208 @default.
- W2028331937 cites W2088601285 @default.
- W2028331937 cites W2089686995 @default.
- W2028331937 cites W2090048744 @default.
- W2028331937 cites W2094604431 @default.
- W2028331937 cites W2100671433 @default.
- W2028331937 cites W2100872688 @default.
- W2028331937 cites W2111809771 @default.
- W2028331937 cites W2115877246 @default.
- W2028331937 cites W2124719436 @default.
- W2028331937 cites W2127247693 @default.
- W2028331937 cites W2135427202 @default.
- W2028331937 cites W2136659777 @default.
- W2028331937 cites W2143547926 @default.
- W2028331937 cites W2148569529 @default.
- W2028331937 cites W2151379283 @default.
- W2028331937 cites W2155315998 @default.
- W2028331937 cites W2155801453 @default.
- W2028331937 cites W2168423079 @default.
- W2028331937 cites W2172252744 @default.
- W2028331937 cites W2376273711 @default.
- W2028331937 cites W268309453 @default.
- W2028331937 cites W2112442563 @default.
- W2028331937 doi "https://doi.org/10.1093/brain/awm328" @default.
- W2028331937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18178568" @default.
- W2028331937 hasPublicationYear "2008" @default.
- W2028331937 type Work @default.
- W2028331937 sameAs 2028331937 @default.
- W2028331937 citedByCount "74" @default.
- W2028331937 countsByYear W20283319372012 @default.
- W2028331937 countsByYear W20283319372013 @default.
- W2028331937 countsByYear W20283319372014 @default.
- W2028331937 countsByYear W20283319372015 @default.
- W2028331937 countsByYear W20283319372016 @default.
- W2028331937 countsByYear W20283319372017 @default.
- W2028331937 countsByYear W20283319372018 @default.
- W2028331937 countsByYear W20283319372019 @default.
- W2028331937 countsByYear W20283319372020 @default.
- W2028331937 countsByYear W20283319372021 @default.
- W2028331937 countsByYear W20283319372022 @default.
- W2028331937 countsByYear W20283319372023 @default.
- W2028331937 crossrefType "journal-article" @default.
- W2028331937 hasAuthorship W2028331937A5006977027 @default.
- W2028331937 hasAuthorship W2028331937A5018649609 @default.
- W2028331937 hasAuthorship W2028331937A5019076928 @default.
- W2028331937 hasAuthorship W2028331937A5031017680 @default.
- W2028331937 hasAuthorship W2028331937A5034889878 @default.
- W2028331937 hasAuthorship W2028331937A5046500154 @default.
- W2028331937 hasAuthorship W2028331937A5060012458 @default.