FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028333721> ?p ?o ?g. }

• W2028333721 endingPage "1341" @default.
• W2028333721 startingPage "1335" @default.
• W2028333721 abstract "The SH3 domain is a versatile protein interaction motif that generally recognizes proline rich sequences (PRS). Recently, it has been shown that some SH3 domains in the endocytotic pathway can bind to ubiquitin. Moreover, Phe73 in the SH3 domain has been proposed to be an important determinant of the interaction, as the SH3 domains having Tyr73, either naturally or by mutation, failed to bind. Since SH3 domains are also important in immune receptor signaling, we investigated the interactions between immunologically relevant SH3 domains and ubiquitin. We observed that some of these SH3 domains can also bind to ubiquitin. Interestingly, we found that Nck2-SH3-3 bound to ubiquitin despite its Tyr at residue 73 (Tyr56 in our actual construct), but that CD2BP1-SH3 failed to bind, even though it has Phe at an equivalent position. Through detailed NMR binding studies on SH3 domains with Phes and Tyrs at the 73 position, we found that the two types of SH3 domains exhibit mechanistic differences in ubiquitin binding. We showed that the relative contribution of each binding sub-region in both SH3 domains and ubiquitin is quite different in the two binding modes. Such results raise the possibility that the mechanistic variety of these immunologically relevant SH3 domains might contribute to their functional diversity." @default.
• W2028333721 created "2016-06-24" @default.
• W2028333721 creator A5003261759 @default.
• W2028333721 creator A5009963704 @default.
• W2028333721 creator A5028979905 @default.
• W2028333721 creator A5064978253 @default.
• W2028333721 creator A5090535135 @default.
• W2028333721 date "2008-09-01" @default.
• W2028333721 modified "2023-10-16" @default.
• W2028333721 title "Distinct interactions between ubiquitin and the SH3 domains involved in immune signaling" @default.
• W2028333721 cites W125596170 @default.
• W2028333721 cites W1589295940 @default.
• W2028333721 cites W1892578325 @default.
• W2028333721 cites W1913862483 @default.
• W2028333721 cites W1921636592 @default.
• W2028333721 cites W1969958451 @default.
• W2028333721 cites W1977425659 @default.
• W2028333721 cites W1983679461 @default.
• W2028333721 cites W1985612204 @default.
• W2028333721 cites W1985663657 @default.
• W2028333721 cites W1987467454 @default.
• W2028333721 cites W1998860600 @default.
• W2028333721 cites W2001892509 @default.
• W2028333721 cites W2002494884 @default.
• W2028333721 cites W2007770027 @default.
• W2028333721 cites W2008219605 @default.
• W2028333721 cites W2008775082 @default.
• W2028333721 cites W2015975352 @default.
• W2028333721 cites W2018407607 @default.
• W2028333721 cites W2031037573 @default.
• W2028333721 cites W2035642251 @default.
• W2028333721 cites W2036644816 @default.
• W2028333721 cites W2039425118 @default.
• W2028333721 cites W2039566055 @default.
• W2028333721 cites W2057934025 @default.
• W2028333721 cites W2064563552 @default.
• W2028333721 cites W2069212881 @default.
• W2028333721 cites W2080716378 @default.
• W2028333721 cites W2090020715 @default.
• W2028333721 cites W2095340557 @default.
• W2028333721 cites W2095495579 @default.
• W2028333721 cites W2097497331 @default.
• W2028333721 cites W2133987610 @default.
• W2028333721 cites W2162651796 @default.
• W2028333721 cites W2171019231 @default.
• W2028333721 cites W45421301 @default.
• W2028333721 doi "https://doi.org/10.1016/j.bbapap.2008.04.031" @default.
• W2028333721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18539162" @default.
• W2028333721 hasPublicationYear "2008" @default.
• W2028333721 type Work @default.
• W2028333721 sameAs 2028333721 @default.
• W2028333721 citedByCount "7" @default.
• W2028333721 countsByYear W20283337212012 @default.
• W2028333721 countsByYear W20283337212013 @default.
• W2028333721 countsByYear W20283337212015 @default.
• W2028333721 countsByYear W20283337212022 @default.
• W2028333721 crossrefType "journal-article" @default.
• W2028333721 hasAuthorship W2028333721A5003261759 @default.
• W2028333721 hasAuthorship W2028333721A5009963704 @default.
• W2028333721 hasAuthorship W2028333721A5028979905 @default.
• W2028333721 hasAuthorship W2028333721A5064978253 @default.
• W2028333721 hasAuthorship W2028333721A5090535135 @default.
• W2028333721 hasConcept C104317684 @default.
• W2028333721 hasConcept C108636557 @default.
• W2028333721 hasConcept C185592680 @default.
• W2028333721 hasConcept C196347352 @default.
• W2028333721 hasConcept C25602115 @default.
• W2028333721 hasConcept C51639874 @default.
• W2028333721 hasConcept C54355233 @default.
• W2028333721 hasConcept C62478195 @default.
• W2028333721 hasConcept C70721500 @default.
• W2028333721 hasConcept C86803240 @default.
• W2028333721 hasConcept C95444343 @default.
• W2028333721 hasConceptScore W2028333721C104317684 @default.
• W2028333721 hasConceptScore W2028333721C108636557 @default.
• W2028333721 hasConceptScore W2028333721C185592680 @default.
• W2028333721 hasConceptScore W2028333721C196347352 @default.
• W2028333721 hasConceptScore W2028333721C25602115 @default.
• W2028333721 hasConceptScore W2028333721C51639874 @default.
• W2028333721 hasConceptScore W2028333721C54355233 @default.
• W2028333721 hasConceptScore W2028333721C62478195 @default.
• W2028333721 hasConceptScore W2028333721C70721500 @default.
• W2028333721 hasConceptScore W2028333721C86803240 @default.
• W2028333721 hasConceptScore W2028333721C95444343 @default.
• W2028333721 hasIssue "9" @default.
• W2028333721 hasLocation W20283337211 @default.
• W2028333721 hasLocation W20283337212 @default.
• W2028333721 hasOpenAccess W2028333721 @default.
• W2028333721 hasPrimaryLocation W20283337211 @default.
• W2028333721 hasRelatedWork W2009043160 @default.
• W2028333721 hasRelatedWork W2028333721 @default.
• W2028333721 hasRelatedWork W2060361484 @default.
• W2028333721 hasRelatedWork W2080716378 @default.
• W2028333721 hasRelatedWork W2093898862 @default.
• W2028333721 hasRelatedWork W2116774289 @default.
• W2028333721 hasRelatedWork W2162492147 @default.
• W2028333721 hasRelatedWork W22226085 @default.
• W2028333721 hasRelatedWork W4254561410 @default.

• next