FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028335218> ?p ?o ?g. }

• W2028335218 abstract "Tumor procoagulant is associated with cancer at advanced stages of malignancy such as infiltration and metastasis. In the present study, we investigated the role of Ley glycolipid in the mechanism of cancer metastasis. Ley glycolipid acts as an important cofactor in the expression of the blood-coagulating activity of cancer cell-derived coagulating activity 1 (CCA-1), which is one of the known tumor procoagulants. Monoclonal antibody (MoAb) FS01, which serves as the Ley-recognizing epitope, inhibits the procoagulant activity of CCA-1 was found to dose-dependently inhibit the procoagulant activity of normal plasma induced by the human lung adenocarcinoma cell line, HAL8, which shows a high level of Ley expression. It did not, however, inhibit the procoagulant activity of the human colon cancer cell line, RPMI4788, which does not express Ley. Administration of FS01 MoAb inhibited lung metastasis of HAL8 cells, but not that of RPMI4788. The absence of antibody-dependent cellular cytotoxicity and complement-mediated cytotoxicity of FS01 MoAb against the HAL8 cell line suggests that the inhibition of HAL8 metastasis by FS01 MoAb derives from the inhibition of blood-coagulating activity of the latter. These findings indicate that Ley glycolipid plays an important role in the mechanism of cancer metastasis via the procoagulant activity of CCA-1." @default.
• W2028335218 created "2016-06-24" @default.
• W2028335218 creator A5008327965 @default.
• W2028335218 creator A5011109613 @default.
• W2028335218 creator A5016303009 @default.
• W2028335218 creator A5019611465 @default.
• W2028335218 creator A5020683329 @default.
• W2028335218 creator A5030372272 @default.
• W2028335218 creator A5048809654 @default.
• W2028335218 creator A5049195602 @default.
• W2028335218 creator A5052154025 @default.
• W2028335218 creator A5054276404 @default.
• W2028335218 creator A5064774655 @default.
• W2028335218 creator A5071694200 @default.
• W2028335218 creator A5076015310 @default.
• W2028335218 creator A5078221062 @default.
• W2028335218 date "2001-11-01" @default.
• W2028335218 modified "2023-09-28" @default.
• W2028335218 title "Ley glycolipid-recognizing monoclonal antibody inhibits procoagulant activity and metastasis of human adenocarcinoma" @default.
• W2028335218 doi "https://doi.org/10.3892/ijo.19.5.941" @default.
• W2028335218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11604991" @default.
• W2028335218 hasPublicationYear "2001" @default.
• W2028335218 type Work @default.
• W2028335218 sameAs 2028335218 @default.
• W2028335218 citedByCount "1" @default.
• W2028335218 crossrefType "journal-article" @default.
• W2028335218 hasAuthorship W2028335218A5008327965 @default.
• W2028335218 hasAuthorship W2028335218A5011109613 @default.
• W2028335218 hasAuthorship W2028335218A5016303009 @default.
• W2028335218 hasAuthorship W2028335218A5019611465 @default.
• W2028335218 hasAuthorship W2028335218A5020683329 @default.
• W2028335218 hasAuthorship W2028335218A5030372272 @default.
• W2028335218 hasAuthorship W2028335218A5048809654 @default.
• W2028335218 hasAuthorship W2028335218A5049195602 @default.
• W2028335218 hasAuthorship W2028335218A5052154025 @default.
• W2028335218 hasAuthorship W2028335218A5054276404 @default.
• W2028335218 hasAuthorship W2028335218A5064774655 @default.
• W2028335218 hasAuthorship W2028335218A5071694200 @default.
• W2028335218 hasAuthorship W2028335218A5076015310 @default.
• W2028335218 hasAuthorship W2028335218A5078221062 @default.
• W2028335218 hasConcept C109316439 @default.
• W2028335218 hasConcept C121608353 @default.
• W2028335218 hasConcept C153911025 @default.
• W2028335218 hasConcept C159654299 @default.
• W2028335218 hasConcept C185592680 @default.
• W2028335218 hasConcept C202751555 @default.
• W2028335218 hasConcept C203014093 @default.
• W2028335218 hasConcept C22222904 @default.
• W2028335218 hasConcept C2779013556 @default.
• W2028335218 hasConcept C2781182431 @default.
• W2028335218 hasConcept C40677261 @default.
• W2028335218 hasConcept C502942594 @default.
• W2028335218 hasConcept C542903549 @default.
• W2028335218 hasConcept C54355233 @default.
• W2028335218 hasConcept C55493867 @default.
• W2028335218 hasConcept C81885089 @default.
• W2028335218 hasConcept C86803240 @default.
• W2028335218 hasConcept C96232424 @default.
• W2028335218 hasConceptScore W2028335218C109316439 @default.
• W2028335218 hasConceptScore W2028335218C121608353 @default.
• W2028335218 hasConceptScore W2028335218C153911025 @default.
• W2028335218 hasConceptScore W2028335218C159654299 @default.
• W2028335218 hasConceptScore W2028335218C185592680 @default.
• W2028335218 hasConceptScore W2028335218C202751555 @default.
• W2028335218 hasConceptScore W2028335218C203014093 @default.
• W2028335218 hasConceptScore W2028335218C22222904 @default.
• W2028335218 hasConceptScore W2028335218C2779013556 @default.
• W2028335218 hasConceptScore W2028335218C2781182431 @default.
• W2028335218 hasConceptScore W2028335218C40677261 @default.
• W2028335218 hasConceptScore W2028335218C502942594 @default.
• W2028335218 hasConceptScore W2028335218C542903549 @default.
• W2028335218 hasConceptScore W2028335218C54355233 @default.
• W2028335218 hasConceptScore W2028335218C55493867 @default.
• W2028335218 hasConceptScore W2028335218C81885089 @default.
• W2028335218 hasConceptScore W2028335218C86803240 @default.
• W2028335218 hasConceptScore W2028335218C96232424 @default.
• W2028335218 hasLocation W20283352181 @default.
• W2028335218 hasLocation W20283352182 @default.
• W2028335218 hasOpenAccess W2028335218 @default.
• W2028335218 hasPrimaryLocation W20283352181 @default.
• W2028335218 hasRelatedWork W1514547987 @default.
• W2028335218 hasRelatedWork W1526523413 @default.
• W2028335218 hasRelatedWork W1559177183 @default.
• W2028335218 hasRelatedWork W1974651044 @default.
• W2028335218 hasRelatedWork W1985614501 @default.
• W2028335218 hasRelatedWork W1997060892 @default.
• W2028335218 hasRelatedWork W2002486286 @default.
• W2028335218 hasRelatedWork W2019294726 @default.
• W2028335218 hasRelatedWork W2024231269 @default.
• W2028335218 hasRelatedWork W2029260618 @default.
• W2028335218 hasRelatedWork W2036096376 @default.
• W2028335218 hasRelatedWork W2062761137 @default.
• W2028335218 hasRelatedWork W2062864283 @default.
• W2028335218 hasRelatedWork W2071360568 @default.
• W2028335218 hasRelatedWork W2108178331 @default.
• W2028335218 hasRelatedWork W2135630623 @default.
• W2028335218 hasRelatedWork W2150926865 @default.
• W2028335218 hasRelatedWork W2409162308 @default.
• W2028335218 hasRelatedWork W2469757353 @default.
• W2028335218 hasRelatedWork W46229805 @default.

• next