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• W2028337377 abstract "Experimental findings on the influence of dementia on pain have so far been conflicting. There is evidence for a decreased, an unchanged and even for an increased pain processing in patients with dementia. The present study was conducted to add on the description of the impact of dementia on pain processing by assessing multiple components of pain (subjective, facial, motor reflex and autonomic responses) in parallel in one group of demented patients. Subjective (rating scale), facial (FACS), motor reflex (NFR) and autonomic (SSR, heart rate) responses to noxious electrical stimulation were assessed in 35 demented patients and 46 aged-matched healthy controls. Stimulus intensities were tailored to the individual NFR threshold. Demented patients rated the stimuli similarly painful as healthy controls did; however, the ability to provide these self-report ratings was markedly diminished in demented patients. Facial responses to noxious stimulation were significantly increased in demented patients. In line with this the NFR threshold was markedly decreased in the patient group. Autonomic responses on the other hand tended to be diminished in patients with dementia. In conclusion, dementia tends to affect different pain components in different ways. Therefore, the assessment of pain in patients with dementia should be based on the measurement of multiple components of pain and not solely on subjective self-report ratings. Furthermore, taking into account our findings on facial responses and the NFR, we think that there is sufficient evidence suggesting a rather intensified processing of noxious stimulation in this patient group." @default.
• W2028337377 created "2016-06-24" @default.
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• W2028337377 date "2009-03-01" @default.
• W2028337377 modified "2023-10-11" @default.
• W2028337377 title "Influence of dementia on multiple components of pain" @default.
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• W2028337377 doi "https://doi.org/10.1016/j.ejpain.2008.05.001" @default.
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