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- W2028337576 abstract "Several studies have been conducted to examine the effects of potassium dichromate on the morphology of renal tissue, but relatively few studies have been done on the functional aspects of the renal damage. This study was designed to examine with in vitro techniques the effects of dichromate on a number of renal tubular transport processes. The accumulation of paraaminohippurate (PAH) and of tetraethylammonium chloride (TEA) by both rat and rabbit slices was inhibited by 10−4 m potassium dichromate added to the bathing solution. On the other hand, the accumulation of the nonmetabolizable amino acid, alpha-aminoisobutyric acid (AIB), was only modestly reduced. In addition, the uptake of TEA was stimulated significantly by low concentrations (10−6 m) of potassium dichromate. Although, in general, similar results were obtained using renal cortical slices taken from pretreated animals significant differences occurred. For example, at none of the doses tested (5–20 mg/kg) was the accumulation of PAH, TEA, or AIB stimulated. This was true whether the measurements were made as soon as 0.5 hr after administration of potassium dichromate or as long as 5 days after its administration. At an intermediate dose of potassium dichromate (10 mg/kg) the lactate-stimulated accumulation of PAH was depressed, but the control or nonsubstrate-stimulated accumulation was not affected. In addition to the effects on uptake of organic compounds, potassium dichromate, whether administered to the intact animal or added to the extra-cellular fluid compartment, caused a decrease in the intracellular concentration of potassium and an increase in the intracellular concentration of sodium. From a quantitative point of view, however, the effect of the nephrotoxin administered to the intact animal was always greater on tissue electrolytes than when the nephrotoxin was added in vitro." @default.
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- W2028337576 title "The effect of potassium dichromate on renal tubular transport processes*1" @default.
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- W2028337576 doi "https://doi.org/10.1016/0041-008x(75)90193-3" @default.
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