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- W2028345325 abstract "Micromagnetic simulation for detecting magnetic beads is performed by using a high-sensitivity spin-valve sensor as the detector. The magnetic beads polarized by a dc magnetic field contribute to a nonuniform dipole field, which can affect the magnetization state of spin-valve sensor, leading to a detectable resistance change. Simulations show that 2μm diam microbeads can be detected with ∼98μV voltage change per bead, which is consistent with the experimental results (∼118μV per bead), indicating that single molecule detection with a micron-sized bead marker is possible. Detection of a single 250nm nanobead shows a sensitivity of ∼34μV, which is close to the present experimental noise level. This suggests that the detection of a single nanosized marker requires enhanced electronic signal by either reducing sensor dimensions or using high-moment ferromagnetic particles as labels." @default.
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- W2028345325 date "2006-04-15" @default.
- W2028345325 modified "2023-09-27" @default.
- W2028345325 title "Micromagnetic simulation for detection of a single magnetic microbead or nanobead by spin-valve sensors" @default.
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- W2028345325 doi "https://doi.org/10.1063/1.2172894" @default.
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