Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028348567> ?p ?o ?g. }
- W2028348567 endingPage "e1669" @default.
- W2028348567 startingPage "e1669" @default.
- W2028348567 abstract "Abstract Knockdown of T-cell intracellular antigens TIA1 and TIAR in transformed cells triggers cell proliferation and tumor growth. Using a tetracycline-inducible system, we report here that an increased expression of TIA1 or TIAR in 293 cells results in reduced rates of cell proliferation. Ectopic expression of these proteins abolish endogenous TIA1 and TIAR levels via the regulation of splicing of their pre-mRNAs, and partially represses global translation in a phospho-eukaryotic initiation factor 2 alpha-dependent manner. This is accompanied by cell cycle arrest at G1/S and cell death through caspase-dependent apoptosis and autophagy. Genome-wide profiling illustrates a selective upregulation of p53 signaling pathway-related genes. Nude mice injected with doxycycline-inducible cells expressing TIA1 or TIAR retard, or even inhibit, growth of xenotumors. Remarkably, low expressions of TIA1 and TIAR correlate with poor prognosis in patients with lung squamous cell carcinoma. These findings strongly support the concept that TIA proteins act as tumor suppressor genes." @default.
- W2028348567 created "2016-06-24" @default.
- W2028348567 creator A5018702088 @default.
- W2028348567 creator A5050723897 @default.
- W2028348567 creator A5084021229 @default.
- W2028348567 date "2015-03-05" @default.
- W2028348567 modified "2023-10-09" @default.
- W2028348567 title "T-cell intracellular antigens function as tumor suppressor genes" @default.
- W2028348567 cites W1489145507 @default.
- W2028348567 cites W1964072966 @default.
- W2028348567 cites W1964719993 @default.
- W2028348567 cites W1969679584 @default.
- W2028348567 cites W1973614363 @default.
- W2028348567 cites W1975676092 @default.
- W2028348567 cites W1983713993 @default.
- W2028348567 cites W1989504358 @default.
- W2028348567 cites W1989549358 @default.
- W2028348567 cites W1993335563 @default.
- W2028348567 cites W1993691900 @default.
- W2028348567 cites W1994823144 @default.
- W2028348567 cites W1994940904 @default.
- W2028348567 cites W2006260717 @default.
- W2028348567 cites W2015384217 @default.
- W2028348567 cites W2015519364 @default.
- W2028348567 cites W2023235837 @default.
- W2028348567 cites W2025722611 @default.
- W2028348567 cites W2028987099 @default.
- W2028348567 cites W2029641128 @default.
- W2028348567 cites W2034847678 @default.
- W2028348567 cites W2038173255 @default.
- W2028348567 cites W2038413819 @default.
- W2028348567 cites W2043435109 @default.
- W2028348567 cites W2047460928 @default.
- W2028348567 cites W2051476388 @default.
- W2028348567 cites W2051669496 @default.
- W2028348567 cites W2054555589 @default.
- W2028348567 cites W2059200009 @default.
- W2028348567 cites W2076495609 @default.
- W2028348567 cites W2080505162 @default.
- W2028348567 cites W2082639157 @default.
- W2028348567 cites W2083827172 @default.
- W2028348567 cites W2085555782 @default.
- W2028348567 cites W2090312211 @default.
- W2028348567 cites W2094122486 @default.
- W2028348567 cites W2098387574 @default.
- W2028348567 cites W2103446696 @default.
- W2028348567 cites W2105694586 @default.
- W2028348567 cites W2106154073 @default.
- W2028348567 cites W2108057660 @default.
- W2028348567 cites W2112015968 @default.
- W2028348567 cites W2115282694 @default.
- W2028348567 cites W2116052270 @default.
- W2028348567 cites W2119176236 @default.
- W2028348567 cites W2134456488 @default.
- W2028348567 cites W2140330371 @default.
- W2028348567 cites W2144280528 @default.
- W2028348567 cites W2152444475 @default.
- W2028348567 cites W2156510716 @default.
- W2028348567 cites W2165948908 @default.
- W2028348567 cites W2167604826 @default.
- W2028348567 cites W2170310644 @default.
- W2028348567 doi "https://doi.org/10.1038/cddis.2015.43" @default.
- W2028348567 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4385921" @default.
- W2028348567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25741594" @default.
- W2028348567 hasPublicationYear "2015" @default.
- W2028348567 type Work @default.
- W2028348567 sameAs 2028348567 @default.
- W2028348567 citedByCount "46" @default.
- W2028348567 countsByYear W20283485672015 @default.
- W2028348567 countsByYear W20283485672016 @default.
- W2028348567 countsByYear W20283485672017 @default.
- W2028348567 countsByYear W20283485672018 @default.
- W2028348567 countsByYear W20283485672019 @default.
- W2028348567 countsByYear W20283485672020 @default.
- W2028348567 countsByYear W20283485672021 @default.
- W2028348567 countsByYear W20283485672022 @default.
- W2028348567 countsByYear W20283485672023 @default.
- W2028348567 crossrefType "journal-article" @default.
- W2028348567 hasAuthorship W2028348567A5018702088 @default.
- W2028348567 hasAuthorship W2028348567A5050723897 @default.
- W2028348567 hasAuthorship W2028348567A5084021229 @default.
- W2028348567 hasBestOaLocation W20283485671 @default.
- W2028348567 hasConcept C104317684 @default.
- W2028348567 hasConcept C127561419 @default.
- W2028348567 hasConcept C153911025 @default.
- W2028348567 hasConcept C173396325 @default.
- W2028348567 hasConcept C190283241 @default.
- W2028348567 hasConcept C54355233 @default.
- W2028348567 hasConcept C62112901 @default.
- W2028348567 hasConcept C86803240 @default.
- W2028348567 hasConcept C95444343 @default.
- W2028348567 hasConcept C97037327 @default.
- W2028348567 hasConceptScore W2028348567C104317684 @default.
- W2028348567 hasConceptScore W2028348567C127561419 @default.
- W2028348567 hasConceptScore W2028348567C153911025 @default.
- W2028348567 hasConceptScore W2028348567C173396325 @default.
- W2028348567 hasConceptScore W2028348567C190283241 @default.
- W2028348567 hasConceptScore W2028348567C54355233 @default.