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- W2028359576 endingPage "13" @default.
- W2028359576 startingPage "1" @default.
- W2028359576 abstract "It is now well established that glial cells not only provide mechanical and trophic support to neurons but can directly contribute to neurotransmission, for example, by release and uptake of neurotransmitters and by secreting pro- and anti-inflammatory mediators. This has greatly changed our attitude towards acute and chronic disorders, paving the way for new therapeutic approaches targeting activated glial cells to indirectly modulate and/or restore neuronal functions. A deeper understanding of the molecular mechanisms and signaling pathways involved in neuron-to-glia and glia-to-glia communication that can be pharmacologically targeted is therefore a mandatory step toward the success of this new healing strategy. This holds true also in the field of pain transmission, where the key involvement of astrocytes and microglia in the central nervous system and satellite glial cells in peripheral ganglia has been clearly demonstrated, and literally hundreds of signaling molecules have been identified. Here, we shall focus on one emerging signaling system involved in the cross talk between neurons and glial cells, the purinergic system, consisting of extracellular nucleotides and nucleosides and their membrane receptors. Specifically, we shall summarize existing evidence of novel “druggable” glial purinergic targets, which could help in the development of innovative analgesic approaches to chronic pain states." @default.
- W2028359576 created "2016-06-24" @default.
- W2028359576 creator A5051019086 @default.
- W2028359576 creator A5053614292 @default.
- W2028359576 date "2014-01-01" @default.
- W2028359576 modified "2023-09-24" @default.
- W2028359576 title "The Purinergic System and Glial Cells: Emerging Costars in Nociception" @default.
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