Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028361569> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2028361569 endingPage "256" @default.
- W2028361569 startingPage "251" @default.
- W2028361569 abstract "Antibodies endowed with hydrolytic properties have been described in humans for over a decade in a variety of pathological conditions such as systemic lupus erythematosus (SLE), autoimmune thyroiditis, asthma, and Bence Jones disease. Although the identified target substrate molecules have always been autoantigens (i.e., DNA, thyroglobulin, vasoactive intestinal peptide), a direct role of hydrolysis of the autoantigen in pathology of the disease has not been clearly documented. We have described in multitransfused patients with hemophilia A the presence of anti-factor VIII (FVIII) IgG antibodies that hydrolyze FVIII. The estimated kinetic parameters derived for FVIII cleavage by anti-FVIII antibodies are in line with the previously described catalytic antibodies. The identified cleavage sites are evenly spread throughout the FVIII molecule and are located after an arginine or a lysine in most cases. We have recently shown that the catalytic antibodies are highly prevalent among hemophilia A patients with FVIII inhibitors. Catalytic antibodies to FVIII are the first example where the hydrolysis of the target molecule by hydrolytic antibodies may be directly relevant to the etiology of the disease. The characterization of FVIII inhibitors as site-specific proteases may provide novel strategies in the design of therapy against FVIII inhibitors in patients with hemophilia A." @default.
- W2028361569 created "2016-06-24" @default.
- W2028361569 creator A5015455280 @default.
- W2028361569 creator A5033562716 @default.
- W2028361569 creator A5036544912 @default.
- W2028361569 creator A5086147416 @default.
- W2028361569 creator A5089079882 @default.
- W2028361569 creator A5089629404 @default.
- W2028361569 date "2002-11-01" @default.
- W2028361569 modified "2023-10-14" @default.
- W2028361569 title "Antibodies with hydrolytic activity towards factor VIII in patients with hemophilia A" @default.
- W2028361569 cites W1482422136 @default.
- W2028361569 cites W1556343014 @default.
- W2028361569 cites W1568247388 @default.
- W2028361569 cites W1572253423 @default.
- W2028361569 cites W1575105525 @default.
- W2028361569 cites W1590814265 @default.
- W2028361569 cites W1965738576 @default.
- W2028361569 cites W1975468167 @default.
- W2028361569 cites W1977971077 @default.
- W2028361569 cites W1998522331 @default.
- W2028361569 cites W1999519260 @default.
- W2028361569 cites W2005791829 @default.
- W2028361569 cites W2006874399 @default.
- W2028361569 cites W2021527012 @default.
- W2028361569 cites W2028148688 @default.
- W2028361569 cites W2042508808 @default.
- W2028361569 cites W2046130452 @default.
- W2028361569 cites W2071314849 @default.
- W2028361569 cites W2083106799 @default.
- W2028361569 cites W2094905385 @default.
- W2028361569 cites W2310992830 @default.
- W2028361569 cites W2403963805 @default.
- W2028361569 cites W90213444 @default.
- W2028361569 cites W98859 @default.
- W2028361569 doi "https://doi.org/10.1016/s0022-1759(02)00235-1" @default.
- W2028361569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12379365" @default.
- W2028361569 hasPublicationYear "2002" @default.
- W2028361569 type Work @default.
- W2028361569 sameAs 2028361569 @default.
- W2028361569 citedByCount "9" @default.
- W2028361569 countsByYear W20283615692013 @default.
- W2028361569 crossrefType "journal-article" @default.
- W2028361569 hasAuthorship W2028361569A5015455280 @default.
- W2028361569 hasAuthorship W2028361569A5033562716 @default.
- W2028361569 hasAuthorship W2028361569A5036544912 @default.
- W2028361569 hasAuthorship W2028361569A5086147416 @default.
- W2028361569 hasAuthorship W2028361569A5089079882 @default.
- W2028361569 hasAuthorship W2028361569A5089629404 @default.
- W2028361569 hasConcept C147483822 @default.
- W2028361569 hasConcept C159654299 @default.
- W2028361569 hasConcept C181199279 @default.
- W2028361569 hasConcept C182220744 @default.
- W2028361569 hasConcept C185592680 @default.
- W2028361569 hasConcept C203014093 @default.
- W2028361569 hasConcept C55493867 @default.
- W2028361569 hasConcept C71924100 @default.
- W2028361569 hasConceptScore W2028361569C147483822 @default.
- W2028361569 hasConceptScore W2028361569C159654299 @default.
- W2028361569 hasConceptScore W2028361569C181199279 @default.
- W2028361569 hasConceptScore W2028361569C182220744 @default.
- W2028361569 hasConceptScore W2028361569C185592680 @default.
- W2028361569 hasConceptScore W2028361569C203014093 @default.
- W2028361569 hasConceptScore W2028361569C55493867 @default.
- W2028361569 hasConceptScore W2028361569C71924100 @default.
- W2028361569 hasIssue "1-2" @default.
- W2028361569 hasLocation W20283615691 @default.
- W2028361569 hasLocation W20283615692 @default.
- W2028361569 hasOpenAccess W2028361569 @default.
- W2028361569 hasPrimaryLocation W20283615691 @default.
- W2028361569 hasRelatedWork W131348366 @default.
- W2028361569 hasRelatedWork W1975407439 @default.
- W2028361569 hasRelatedWork W19856627 @default.
- W2028361569 hasRelatedWork W2040191638 @default.
- W2028361569 hasRelatedWork W2048473435 @default.
- W2028361569 hasRelatedWork W2120422181 @default.
- W2028361569 hasRelatedWork W2404646868 @default.
- W2028361569 hasRelatedWork W2748952813 @default.
- W2028361569 hasRelatedWork W2899084033 @default.
- W2028361569 hasRelatedWork W940191291 @default.
- W2028361569 hasVolume "269" @default.
- W2028361569 isParatext "false" @default.
- W2028361569 isRetracted "false" @default.
- W2028361569 magId "2028361569" @default.
- W2028361569 workType "article" @default.