Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028364955> ?p ?o ?g. }
- W2028364955 endingPage "527" @default.
- W2028364955 startingPage "511" @default.
- W2028364955 abstract "The gaseous XO molecules (X = C, N or O) bind to the heme prosthetic group of heme proteins, and thereby activate or inhibit key biological processes. These events depend on interactions of the surrounding protein with the FeXO adduct, interactions that can be monitored via the frequencies of the Fe-X and X-O bond stretching modes, νFeX and νXO. The frequencies can be determined by vibrational spectroscopy, especially resonance Raman spectroscopy. Backbonding, the donation of Fe dπ electrons to the XO π* orbitals, is a major bonding feature in all the FeXO adducts. Variations in backbonding produce negative νFeX/νXO correlations, which can be used to gauge electrostatic and H-bonding effects in the protein binding pocket. Backbonding correlations have been established for all the FeXO adducts, using porphyrins with electron donating and withdrawing substituents. However the adducts differ in their response to variations in the nature of the axial ligand, and to specific distal interactions. These variations provide differing vantages for evaluating the nature of protein-heme interactions. We review experimental studies that explore these variations, and DFT computational studies that illuminate the underlying physical mechanisms." @default.
- W2028364955 created "2016-06-24" @default.
- W2028364955 creator A5070326580 @default.
- W2028364955 creator A5082499974 @default.
- W2028364955 creator A5090646815 @default.
- W2028364955 date "2013-01-01" @default.
- W2028364955 modified "2023-09-29" @default.
- W2028364955 title "CO, NO and O2 as vibrational probes of heme protein interactions" @default.
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