FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028367089> ?p ?o ?g. }

• W2028367089 endingPage "491" @default.
• W2028367089 startingPage "486" @default.
• W2028367089 abstract "Expression and gain-of-function mutation of the c-kit gene, that encodes a receptor tyrosine kinase (KIT), have been reported in mast cell tumors and gastrointestinal stromal tumors (GISTs). Among human testicular germ cell tumors (GCTs), seminomas and seminoma components of mixed GCTs have also been shown to express KIT, but only one study has found the c-kit gene mutation at exon 17 in seminoma. To elucidate the frequency and location of the c-kit gene mutation of testicular GCTs, we analyzed the whole coding region of the c-kit complementary DNA along with 4 mutational hot spots (exons 9, 11, 13 and 17) of the c-kit genomic DNA by polymerase chain reaction and direct sequencing. Somatic mutations were found in 4 pure seminomas of 34 testicular GCTs (11.8%). One mutation was found in exon 11 (W557R) and the others were observed in exon 17 (D816H and D816V). These types of mutations were reported in GISTs (W557R), seminoma (D816H) and mastocytosis (D816V) and were considered to be gain-of-function mutations, although there were no differences of any clinicopathological factors or outcome between patients with and without mutations. Additionally, we also demonstrated coexpression of Gly-Asn-Asn-Lys510-513 (GNNK) + and GNNK - isoforms of the c-kit gene with dominance of the GNNK - transcript in all testicular GCTs. The mutations and/or preferential expression of GNNK - isoform of the c-kit gene might play an important role in the development of testicular GCTs, and these tumors may also be targets for STI571, which is a promising drug for advanced and metastatic GISTs." @default.
• W2028367089 created "2016-06-24" @default.
• W2028367089 creator A5018139084 @default.
• W2028367089 creator A5029513678 @default.
• W2028367089 creator A5063352822 @default.
• W2028367089 creator A5067592383 @default.
• W2028367089 creator A5076142771 @default.
• W2028367089 date "2003-06-01" @default.
• W2028367089 modified "2023-10-16" @default.
• W2028367089 title "Alterations of the c-kit gene in testicular germ cell tumors" @default.
• W2028367089 cites W180606804 @default.
• W2028367089 cites W1966822439 @default.
• W2028367089 cites W1970226788 @default.
• W2028367089 cites W1972284797 @default.
• W2028367089 cites W1984578995 @default.
• W2028367089 cites W2000998080 @default.
• W2028367089 cites W2004137809 @default.
• W2028367089 cites W2011144636 @default.
• W2028367089 cites W2015015957 @default.
• W2028367089 cites W2016899343 @default.
• W2028367089 cites W2021997509 @default.
• W2028367089 cites W2037957809 @default.
• W2028367089 cites W2039037540 @default.
• W2028367089 cites W2060970776 @default.
• W2028367089 cites W2060975018 @default.
• W2028367089 cites W2077976050 @default.
• W2028367089 cites W2085001173 @default.
• W2028367089 cites W2095226581 @default.
• W2028367089 cites W2105396280 @default.
• W2028367089 cites W2106037057 @default.
• W2028367089 cites W2119323720 @default.
• W2028367089 cites W2119455657 @default.
• W2028367089 cites W2130755604 @default.
• W2028367089 cites W2139524845 @default.
• W2028367089 cites W2156160133 @default.
• W2028367089 cites W2165720262 @default.
• W2028367089 cites W2171620774 @default.
• W2028367089 doi "https://doi.org/10.1111/j.1349-7006.2003.tb01470.x" @default.
• W2028367089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12824871" @default.
• W2028367089 hasPublicationYear "2003" @default.
• W2028367089 type Work @default.
• W2028367089 sameAs 2028367089 @default.
• W2028367089 citedByCount "98" @default.
• W2028367089 countsByYear W20283670892012 @default.
• W2028367089 countsByYear W20283670892013 @default.
• W2028367089 countsByYear W20283670892014 @default.
• W2028367089 countsByYear W20283670892015 @default.
• W2028367089 countsByYear W20283670892016 @default.
• W2028367089 countsByYear W20283670892017 @default.
• W2028367089 countsByYear W20283670892018 @default.
• W2028367089 countsByYear W20283670892019 @default.
• W2028367089 countsByYear W20283670892020 @default.
• W2028367089 countsByYear W20283670892022 @default.
• W2028367089 countsByYear W20283670892023 @default.
• W2028367089 crossrefType "journal-article" @default.
• W2028367089 hasAuthorship W2028367089A5018139084 @default.
• W2028367089 hasAuthorship W2028367089A5029513678 @default.
• W2028367089 hasAuthorship W2028367089A5063352822 @default.
• W2028367089 hasAuthorship W2028367089A5067592383 @default.
• W2028367089 hasAuthorship W2028367089A5076142771 @default.
• W2028367089 hasBestOaLocation W20283670891 @default.
• W2028367089 hasConcept C104317684 @default.
• W2028367089 hasConcept C109159458 @default.
• W2028367089 hasConcept C134305767 @default.
• W2028367089 hasConcept C13514818 @default.
• W2028367089 hasConcept C153911025 @default.
• W2028367089 hasConcept C2022786 @default.
• W2028367089 hasConcept C2776694085 @default.
• W2028367089 hasConcept C2776938808 @default.
• W2028367089 hasConcept C2778074268 @default.
• W2028367089 hasConcept C2779122487 @default.
• W2028367089 hasConcept C28328180 @default.
• W2028367089 hasConcept C2910840531 @default.
• W2028367089 hasConcept C2994225774 @default.
• W2028367089 hasConcept C36823959 @default.
• W2028367089 hasConcept C501734568 @default.
• W2028367089 hasConcept C502942594 @default.
• W2028367089 hasConcept C54355233 @default.
• W2028367089 hasConcept C86803240 @default.
• W2028367089 hasConceptScore W2028367089C104317684 @default.
• W2028367089 hasConceptScore W2028367089C109159458 @default.
• W2028367089 hasConceptScore W2028367089C134305767 @default.
• W2028367089 hasConceptScore W2028367089C13514818 @default.
• W2028367089 hasConceptScore W2028367089C153911025 @default.
• W2028367089 hasConceptScore W2028367089C2022786 @default.
• W2028367089 hasConceptScore W2028367089C2776694085 @default.
• W2028367089 hasConceptScore W2028367089C2776938808 @default.
• W2028367089 hasConceptScore W2028367089C2778074268 @default.
• W2028367089 hasConceptScore W2028367089C2779122487 @default.
• W2028367089 hasConceptScore W2028367089C28328180 @default.
• W2028367089 hasConceptScore W2028367089C2910840531 @default.
• W2028367089 hasConceptScore W2028367089C2994225774 @default.
• W2028367089 hasConceptScore W2028367089C36823959 @default.
• W2028367089 hasConceptScore W2028367089C501734568 @default.
• W2028367089 hasConceptScore W2028367089C502942594 @default.
• W2028367089 hasConceptScore W2028367089C54355233 @default.
• W2028367089 hasConceptScore W2028367089C86803240 @default.
• W2028367089 hasIssue "6" @default.

• next