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- W2028372640 abstract "Abstract A reversed-phase high-performance liquid chromatographic method was developed for the simultaneous determination of chloramphenicol and benzocaine in topical solutions and suppositories. The method was statistically evaluated for its accuracy and precision in the assay of chloramphenicol and benzocaine in commercial pharmaceutical preparations. Excipients and impurities normally present did not interfere, and the mean recoveries were 99.68% (R.S.D. 1.20%) for benzocaine and 99.96% (R.S.D. 0.66%) for chloramphenicol. A Waters Assoc. Guard-Pak precolumn module with a μBondapak C 18 precolumn was utilized to protect the analytical column from contamination. The ratio-plotting technique was used to confirm the non-interference of excipients and other impurities with the peak of interest from formulations, and for validation of the method." @default.
- W2028372640 created "2016-06-24" @default.
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- W2028372640 date "1991-01-01" @default.
- W2028372640 modified "2023-09-30" @default.
- W2028372640 title "Simultaneous determination of chloramphenicol and benzocaine in topical formulations by high-performance liquid chromatography" @default.
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- W2028372640 doi "https://doi.org/10.1016/s0021-9673(01)88786-0" @default.
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