Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028375949> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2028375949 endingPage "210" @default.
- W2028375949 startingPage "205" @default.
- W2028375949 abstract "Recent studies have demonstrated the vulnerability of dentate mossy cells to seizure-induced damage. One source of potentially damaging synaptic input are spontaneously active granule cell terminals ('mossy terminals'.) We sought to test whether there were activity-dependent changes in the spontaneous excitatory input to mossy cells. Using the in vitro slice preparation, we examined the frequency and amplitude of spontaneous excitatory postsynaptic potentials (EPSPs) after intracellular current injection designed to mimic the extreme depolarization these neurons receive during repetitive afferent stimulation. In 4 of 7 neurons, depolarization with trains of current pulses resulted in a significant and persistent increase in frequency of spontaneous synaptic depolarizations (to an average of 178% of the initial baseline rate). In 3 of these affected neurons, an increased frequency of large amplitude, fast-rising EPSPs accounted for the majority of this change. Injection of hyperpolarizing current pulses failed to alter spontaneous activity in 3 other mossy cells. These results suggest spontaneous synaptic input to mossy cells in plastic and can be potentiated by depolarization of a single postsynaptic mossy cell. The ability of mossy cells to potentiate their excitatory input may be relevant to their vulnerability to excitotoxic injury during repetitive afferent stimulation." @default.
- W2028375949 created "2016-06-24" @default.
- W2028375949 creator A5011927785 @default.
- W2028375949 creator A5017440715 @default.
- W2028375949 creator A5039203405 @default.
- W2028375949 date "1992-08-01" @default.
- W2028375949 modified "2023-10-16" @default.
- W2028375949 title "Potentiation of spontaneous synaptic activity in rat mossy cells" @default.
- W2028375949 cites W1964613403 @default.
- W2028375949 cites W1981378777 @default.
- W2028375949 cites W1997765501 @default.
- W2028375949 cites W2042315877 @default.
- W2028375949 cites W2045086903 @default.
- W2028375949 cites W2048145476 @default.
- W2028375949 cites W2056992784 @default.
- W2028375949 cites W2057608535 @default.
- W2028375949 cites W2059658339 @default.
- W2028375949 cites W2065412452 @default.
- W2028375949 cites W2080130890 @default.
- W2028375949 cites W2083479482 @default.
- W2028375949 cites W2096428903 @default.
- W2028375949 cites W2114289240 @default.
- W2028375949 cites W2139720686 @default.
- W2028375949 cites W2142925815 @default.
- W2028375949 cites W21559756 @default.
- W2028375949 cites W2436435546 @default.
- W2028375949 doi "https://doi.org/10.1016/0304-3940(92)90374-g" @default.
- W2028375949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1454217" @default.
- W2028375949 hasPublicationYear "1992" @default.
- W2028375949 type Work @default.
- W2028375949 sameAs 2028375949 @default.
- W2028375949 citedByCount "22" @default.
- W2028375949 countsByYear W20283759492013 @default.
- W2028375949 countsByYear W20283759492016 @default.
- W2028375949 countsByYear W20283759492018 @default.
- W2028375949 crossrefType "journal-article" @default.
- W2028375949 hasAuthorship W2028375949A5011927785 @default.
- W2028375949 hasAuthorship W2028375949A5017440715 @default.
- W2028375949 hasAuthorship W2028375949A5039203405 @default.
- W2028375949 hasConcept C112592302 @default.
- W2028375949 hasConcept C118232355 @default.
- W2028375949 hasConcept C12554922 @default.
- W2028375949 hasConcept C169760540 @default.
- W2028375949 hasConcept C170493617 @default.
- W2028375949 hasConcept C17077164 @default.
- W2028375949 hasConcept C185592680 @default.
- W2028375949 hasConcept C197341189 @default.
- W2028375949 hasConcept C200170125 @default.
- W2028375949 hasConcept C25274449 @default.
- W2028375949 hasConcept C4141045 @default.
- W2028375949 hasConcept C55493867 @default.
- W2028375949 hasConcept C86803240 @default.
- W2028375949 hasConceptScore W2028375949C112592302 @default.
- W2028375949 hasConceptScore W2028375949C118232355 @default.
- W2028375949 hasConceptScore W2028375949C12554922 @default.
- W2028375949 hasConceptScore W2028375949C169760540 @default.
- W2028375949 hasConceptScore W2028375949C170493617 @default.
- W2028375949 hasConceptScore W2028375949C17077164 @default.
- W2028375949 hasConceptScore W2028375949C185592680 @default.
- W2028375949 hasConceptScore W2028375949C197341189 @default.
- W2028375949 hasConceptScore W2028375949C200170125 @default.
- W2028375949 hasConceptScore W2028375949C25274449 @default.
- W2028375949 hasConceptScore W2028375949C4141045 @default.
- W2028375949 hasConceptScore W2028375949C55493867 @default.
- W2028375949 hasConceptScore W2028375949C86803240 @default.
- W2028375949 hasIssue "2" @default.
- W2028375949 hasLocation W20283759491 @default.
- W2028375949 hasLocation W20283759492 @default.
- W2028375949 hasOpenAccess W2028375949 @default.
- W2028375949 hasPrimaryLocation W20283759491 @default.
- W2028375949 hasRelatedWork W1643544035 @default.
- W2028375949 hasRelatedWork W2024618975 @default.
- W2028375949 hasRelatedWork W2032702806 @default.
- W2028375949 hasRelatedWork W2037415070 @default.
- W2028375949 hasRelatedWork W2048465471 @default.
- W2028375949 hasRelatedWork W2051218611 @default.
- W2028375949 hasRelatedWork W2057338618 @default.
- W2028375949 hasRelatedWork W2308145636 @default.
- W2028375949 hasRelatedWork W2400254911 @default.
- W2028375949 hasRelatedWork W2405625631 @default.
- W2028375949 hasVolume "142" @default.
- W2028375949 isParatext "false" @default.
- W2028375949 isRetracted "false" @default.
- W2028375949 magId "2028375949" @default.
- W2028375949 workType "article" @default.