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- W2028378593 abstract "The entry into the circulation of malignant cells from two metastases forming tumors, i.e., the first phase of metastases formation, was studied in subcutaneous W/Fu AML and B16/BL-6 syngeneic tumor transplants in rats and mice, respectively. Both tumors formed metastases and invaded neighboring tissues. Malignant cells of both tumors entered the circulation by penetrating the intact endothelial cell body. The migration pore thus formed by the migrating cell closed after the cell had reached the intravascular space. Thus, the pathway of malignant cells is transcellular. There was no destructive invasion of the vessel wall by malignant cells, which resulted in patent defects. This mode of entry into the circulation by malignant cells was found in the venules of (and induced by) the tumor and, although with less frequency, in the walls of preexisting veins." @default.
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- W2028378593 date "1982-11-01" @default.
- W2028378593 modified "2023-10-13" @default.
- W2028378593 title "Vascular endothelial invasion via transcellular passage by malignant cells in the primary stage of metastases formation" @default.
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- W2028378593 doi "https://doi.org/10.1016/s0022-5320(82)90075-2" @default.
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