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- W2028379729 endingPage "136" @default.
- W2028379729 startingPage "106" @default.
- W2028379729 abstract "A successful pregnancy requires multiple adaptations in the mother's brain that serve to optimise foetal growth and development, protect the foetus from adverse prenatal programming and prevent premature delivery of the young. Pregnancy hormones induce, organise and maintain many of these adaptations. Steroid hormones play a critical role and of particular importance is the progesterone metabolite and neurosteroid, allopregnanolone. Allopregnanolone is produced in increasing amounts during pregnancy both in the periphery and in the maternal and foetal brain. This review critically examines a role for allopregnanolone in both the maternal and foetal brain during pregnancy and development in protecting pregnancy and birth outcomes, with particular emphasis on its role in relation to stress exposure at this time. Late pregnancy is associated with suppressed stress responses. Thus, we begin by considering what is known about the central mechanisms in the maternal brain, induced by allopregnanolone, that protect the foetus(es) from exposure to harmful levels of maternal glucocorticoids as a result of stress during pregnancy. Next we discuss the central mechanisms that prevent premature secretion of oxytocin and consider a role for allopregnanolone in minimising the risk of preterm birth. Allopregnanolone also plays a key role in the foetal brain, where it promotes development and is neuroprotective. Hence we review the evidence about disruption to neurosteroid production in pregnancy, through prenatal stress or other insults, and the immediate and long-term adverse consequences for the offspring. Finally we address whether progesterone or allopregnanolone treatment can rescue some of these deficits in the offspring." @default.
- W2028379729 created "2016-06-24" @default.
- W2028379729 creator A5038391174 @default.
- W2028379729 creator A5060135354 @default.
- W2028379729 creator A5077217228 @default.
- W2028379729 date "2014-02-01" @default.
- W2028379729 modified "2023-10-10" @default.
- W2028379729 title "Allopregnanolone in the brain: Protecting pregnancy and birth outcomes" @default.
- W2028379729 cites W1265796269 @default.
- W2028379729 cites W1484168868 @default.
- W2028379729 cites W1487226122 @default.
- W2028379729 cites W1496961660 @default.
- W2028379729 cites W1499904716 @default.
- W2028379729 cites W1505876840 @default.
- W2028379729 cites W151479961 @default.
- W2028379729 cites W1519441922 @default.
- W2028379729 cites W1519557516 @default.
- W2028379729 cites W1529067373 @default.
- W2028379729 cites W1531765500 @default.
- W2028379729 cites W1534552882 @default.
- W2028379729 cites W1541228389 @default.
- W2028379729 cites W1541257414 @default.
- W2028379729 cites W1548044390 @default.
- W2028379729 cites W1581750414 @default.
- W2028379729 cites W1586163514 @default.
- W2028379729 cites W1588928891 @default.
- W2028379729 cites W1590768477 @default.
- W2028379729 cites W1594120948 @default.
- W2028379729 cites W1610317794 @default.
- W2028379729 cites W1620990221 @default.
- W2028379729 cites W1678261667 @default.
- W2028379729 cites W1703928389 @default.
- W2028379729 cites W1864733621 @default.
- W2028379729 cites W1906690582 @default.
- W2028379729 cites W1907399600 @default.
- W2028379729 cites W1912022866 @default.
- W2028379729 cites W1916395565 @default.
- W2028379729 cites W1917775227 @default.
- W2028379729 cites W1965160371 @default.
- W2028379729 cites W1965367648 @default.
- W2028379729 cites W1966685847 @default.
- W2028379729 cites W1968226169 @default.
- W2028379729 cites W1968427184 @default.
- W2028379729 cites W1968463396 @default.
- W2028379729 cites W1969009804 @default.
- W2028379729 cites W1970590111 @default.
- W2028379729 cites W1971357456 @default.
- W2028379729 cites W1971616915 @default.
- W2028379729 cites W1972097431 @default.
- W2028379729 cites W1972240031 @default.
- W2028379729 cites W1972470488 @default.
- W2028379729 cites W1972511187 @default.
- W2028379729 cites W1973115552 @default.
- W2028379729 cites W1973518997 @default.
- W2028379729 cites W1973557149 @default.
- W2028379729 cites W1973783162 @default.
- W2028379729 cites W1973867244 @default.
- W2028379729 cites W1974197763 @default.
- W2028379729 cites W1976995330 @default.
- W2028379729 cites W1979295154 @default.
- W2028379729 cites W1980011151 @default.
- W2028379729 cites W1980099277 @default.
- W2028379729 cites W1981864267 @default.
- W2028379729 cites W1981877284 @default.
- W2028379729 cites W1983286282 @default.
- W2028379729 cites W1984313653 @default.
- W2028379729 cites W1985656087 @default.
- W2028379729 cites W1987140375 @default.
- W2028379729 cites W1987263856 @default.
- W2028379729 cites W1987379593 @default.
- W2028379729 cites W1988626231 @default.
- W2028379729 cites W1989597801 @default.
- W2028379729 cites W1990623083 @default.
- W2028379729 cites W1990792580 @default.
- W2028379729 cites W1992731266 @default.
- W2028379729 cites W1992879638 @default.
- W2028379729 cites W1993098410 @default.
- W2028379729 cites W1993159694 @default.
- W2028379729 cites W1994010754 @default.
- W2028379729 cites W1994288122 @default.
- W2028379729 cites W1994345705 @default.
- W2028379729 cites W1994412989 @default.
- W2028379729 cites W1994740828 @default.
- W2028379729 cites W1995289422 @default.
- W2028379729 cites W1995774252 @default.
- W2028379729 cites W1997395738 @default.
- W2028379729 cites W1998502966 @default.
- W2028379729 cites W1999048193 @default.
- W2028379729 cites W2000510980 @default.
- W2028379729 cites W2000712333 @default.
- W2028379729 cites W2000714241 @default.
- W2028379729 cites W2001017562 @default.
- W2028379729 cites W2001971957 @default.
- W2028379729 cites W2002172124 @default.
- W2028379729 cites W2002284033 @default.
- W2028379729 cites W2002862204 @default.
- W2028379729 cites W2002947389 @default.
- W2028379729 cites W2003772211 @default.